Imagine you have used cBioportal and breast cancer patient datasets and identified a cancer-associated mutation in a particular protein. What would you do next to understand whether that mutation contributes to tumor progression (include experimental approach)?

Q: https://www.mskcc.org/news/mystery-metastasis-can-tumor-s-genetic-mutations-predict-whether-and-wher…

A: Cells are the building clocks of life. The structural and functional units of life are cells.  Cells…

Q: Which of the following is the best example of a tumor promoter? A chemical that allows cells to…

A: Answer : Option B- a chemical that activates mTOR.  Tumour promotors are agents or chemicals that…

Q: Which of the following statements about tumor suppressor genes is FALSE? a) Inactivation of tumor…

A: False statement about tumor suppressor genes.

Q: Which of the following best describes a gene that codes for a tumor-suppressor protein? a. One that…

A: Cell growth is the process by which cells gain mass and expand in size. Animal cells that are…

Q: Which of the following is NOT an example of fail-safe mechanisms that prevent the irregular cell…

A: Cancer is the uncontrolled cell division where he ell continuously divides. Cancer cells thus become…

Q: What is the difference between an oncogene and a tumor-suppressor gene? Give some examples of the…

A: Cell proliferation, cell differentiation, and cell survival are under the control of some critical…

Q: Characterize the differences between tumor cells and normal cells in terms of the following…

A: A. The normal cell shows contact inhibition that means when two cells get contact then the growth…

Q: Give two examples of how genomic studies have altered our understanding of cancers.

A: Cancer was initially described by Hippocrates when he identified two forms of cancer: ulcer forming…

Q: Describe three popular methods for silencing tumor-suppressor genes.

A: Introduction Tumor suppressor genes are those that slow down the division and development of cells.…

Q: Mammography is an accurate screening technique for the earlydetection of breast cancer in humans.…

A: Cancer is a devastating medical condition characterized by the growth of abnormal cells in the body…

Q: Which of the following must scientists understand in order to create effective cancer treatments?…

A: Effective cancer treatment in the order of b a d c. b. Where cancer originated : Scientists first…

Q: Which of the following is NOT an example of a fail-safe mechanism that prevents the irregular cell…

A: Uncontrolled cell division results in the development of a tumor or cancer. There are many factors…

Q: Stem Cells and Tissue Renewal. Use the topic and relate the topic for initiation progression and…

A: we have different types of tissues in the body . stem cells are very basic but unique cells such…

Q: Explain why some researchers believe science should focus its attention on the inflammation…

A: The uncontrolled growth of cells leads to cancer progression.

Q: advantages and limitations of circulating tumor dna

A: The disease in which abnormal cells continuously grow and divide spreading to other tissue is known…

Q: Compare and contrast oncogenes and tumor suppressor genes.

A: Oncogenes are those genes that have the potential to cause cancer. These genes are often mutated or…

Q: Which of the following is not a tumor suppressor gene? a.RET b.RB c.BRCA1 d.BRCA2

A: A normal cell undergoes regulated division, differentiation, and apoptosis (programmed cell death).…

Q: Discuss the interplay between genetics and environment in the development of cancer (it would be…

A: Research on several diseases have found that the cause of diseases are not only environmental or…

Q: Normal (nonmutant) tumor-suppressor genes often functiona. as negative regulators of cell…

A: Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell…

Q: Suppose Nicole recently learned that she inherited a mutant BRCA1 allele from her mother, who had…

A: BRCA1 is a tumor suppressor gene usually expressed in breast cells. It is responsible for repairing…

Q: Imagine that you are a scientist who wants to better understand the genetic mechanisms underlying…

A: Mus musculus is an experimental model organism that allows researchers to test the role of certain…

Q: Unlike many other diseases, the vast majority of cancers in humans are not transmissible - meaning a…

A: Cancer is "referred" to as any abnormal growth of cell tissue. Cancer can develop anywhere in the…

Q: Much remains unknown about the rapid, uncontrolled growth, or what causes a tumor to metastasize.…

A: Cancer is a disease in which abnormal cells divide uncontrollably and destroy body tissue. A…

Q: In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an…

A: Cancer is an uncontrolled division of cell that has a defunct apoptosis mechanism. Usually, when…

Q: The "initiation" stage of cancer refers to:     a)  The stage where DNA is mutated, and permanent…

A: Introduction :  Cancer is defined by the following characteristics: • Uncontrolled…

Q: Many of the mutations in cancer samples are not necessarily driver mutations, but rather passenger…

A: Hematologic childhood cancer can develop in any part of the body, including the blood and lymph…

Q: Which of the following statements about cancer is false? (a) oncogenes arise from mutations in…

A: Proto Oncogenes are the genes that cause cancer when there are alterations in them. Several factors…

Q: Explain the difference between proto-oncogene and tumor suppressor mutations in terms of its…

A: Cancer is a medical condition that is characterized by the growth of tumors in the body of an…

Q: Drivers are mutations that drive the cancer process; passengers are mutations that arise randomly in…

A: Cancer is the uncontrolled division or growth of the cells. The causes of cancer differ widely but…

Q: Cells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene…

A: An oncogene helps in control cell division and  contributes to cancer progression whereas a tumor…

Q: Which of the following chromosomal changes would be LEAST likely to cause the development of cancer?…

A: Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably.…

Q: proto-oncogenes and tumor suppressor genes cause most types of cancer

A: The genes are formed by the Deoxyribonucleic acid (DNA) of an organism. These genes code all of the…

Q: A tumor suppressor gene (TSG) codes for a protein that is part of the system that regulates cell…

A: Normal genes that halt cell division or fix DNA errors are known as tumor suppressor genes. Such…

Q: Which of the following effectively describes the situation of someone with an inherited…

A: Breast cancer is a condition in which abnormal cells in the breast grow uncontrolled, resulting in a…

Q: Apart from p53, mention and describe the function of three tumor suppressor genes you know

A: The cancer related genes can be divided into two broad categories like the proto-oncogenes and tumor…

Q: Which of the following statements correctly describes a characteristic of tumor-suppressor gene? a)…

A: Cells that progress through the cell cycle unchecked may sequentially develop malignant tumors.…

Q: Cancer is related to cellular errors during certain mechanisms and due to certain factors yet, the…

A: Uncontrolled cell division result into cancer.  Cancer cells grow in large size and take on the…

Q: Tumor-suppressor genes promote cancer whena. they are overexpressed.b. they are expressed in the…

A: Cancer is a disorder in which abnormal cells divide irrepressibly and destroy the tissues of the…

Q: Part A and B A. What are the Hallmarks of Cancer? A) Criteria that are used to identify tumors in…

A: The hallmarks of cancer are the biological capabilities that are required during the development of…

Q: ''The main environmental causes of cancer are theproducts of our highly industrialized way of life…

A: Cancer: It is a disease where cells divide abnormally and damage other cells. There are different…

Q: a. How could you use sequence analysis to determine if this patient inherited the mutation from one…

A: There are various diagnostic technique used to diagnose cancer and they are:- Biopsy, Breast MRI,…

Q: Which of the following is an enabling characteristic for cancer that can increase the likelihood of…

A: The somatic mutations in the genome of a cancer cell, irrespective of their structural nature, can…

Q: Explain Mutations in tumor-suppressor genes are recessive at the cellular level but dominant at the…

A: Cancer is a group of diseases involving abnormal growth of cells, which tend to proliferate in an…

Q: Please give information and explain the modeling of cancer with IPS cells (induced pluripotent stem…

A: The discovery of iPS cells opens up a wide spectrum of possible future applications including…

Q: With regard to cancer cells, which of the following statementsare true?A. Cancer cells are clonal,…

A: Cancer is a group of diseases involving abnormal growth of cells, which tend to proliferate in an…

Q: Match each definition with the corresponding term concerning genes involved in tumor formation.…

A: Cancer is a very complex molecular disease that occurs due to the uncontrolled cell division.…

Q: Explain the difference between a proto-oncogene and a tumor-suppressor gene.

A: Cancer is the state of uncontrolled cell division.

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.