Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 5, Problem 2ITD
Some cancer cells are insensitive to typical chemotherapy. Research into the mechanisms underlying this insensitivity uncovered an ability by these cells to “pump” the treatment drug out of the cell against its concentration gradient. Additional drugs have been developed that inhibit the pump, thus trapping the chemotherapeutic agent inside to promote cancer cell destruction. The Figure shows what happens when two types of cells are treated with a 3H-labeled anti-cancer drug, paclitaxel.
Two additional drugs, imatinib and nilotinib, are evaluated for their ability to overcome the cancer cells’ ability to “pump out” the chemotherapeutic agent. An asterisk (*) indicates a statistically significant difference from the cells receiving paclitaxel alone. Do the additional drugs seem to the effective in over-coming the pump? Which set of graphs (A or B) best supports your answer? Explain your answer.
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Chapter 5 Solutions
Biology: The Dynamic Science (MindTap Course List)
Ch. 5.1 - Describe the fluid mosaic model for membrane...Ch. 5.1 - Give two examples each of integral proteins and...Ch. 5.2 - What is the difference between passive and active...Ch. 5.2 - Prob. 2SBCh. 5.3 - Prob. 1SBCh. 5.3 - Prob. 2SBCh. 5.4 - Prob. 1SBCh. 5.4 - Prob. 2SBCh. 5.5 - Prob. 1SBCh. 5.5 - Prob. 2SB
Ch. 5 - In the fluid mosaic model: plasma membrane...Ch. 5 - Which of the following statements is false?...Ch. 5 - The freeze-fracture technique demonstrated: a....Ch. 5 - A characteristic of carrier molecules in a primary...Ch. 5 - A driving ion moving through a membrane channel in...Ch. 5 - Phagocytosis illustrates which phenomenon? a....Ch. 5 - Place in order the following events of...Ch. 5 - Prob. 8TYKCh. 5 - Which of the following statements is true for the...Ch. 5 - Using the principle of diffusion, a dialysis...Ch. 5 - Discuss Concepts The bacterium Vibrio cholera...Ch. 5 - Prob. 12TYKCh. 5 - Prob. 13TYKCh. 5 - Prob. 15TYKCh. 5 - Some cancer cells are insensitive to typical...Ch. 5 - Some cancer cells are insensitive to typical...
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- Some cancer cells are insensitive to typical chemotherapy. Research into the mechanisms underlying this insensitivity uncovered an ability by these cells to pump the treatment drug out of the cell against its concentration gradient. Additional drugs have been developed that inhibit the pump, thus trapping the chemotherapeutic agent inside to promote cancer cell destruction. The Figure shows what happens when two types of cells are treated with a 3H-labeled anti-cancer drug, paclitaxel. Which set of cells (A or B) would be described as resistant to the cancer treatment? Explain your answer. What type of transport are the resistant cells using?arrow_forwardAnother model, the random model, proposes that any cell in a malignant tumor has the potential to form a new tumor. Does the cancer stem cell hypothesis contradict this idea?arrow_forwardCancer cells may be more susceptible than normal cells to mitotic catastrophe in response to chemotherapeutic drugs because of which of the following (select all that apply)? A. They express unique receptors for those drugs on their surface B. They may be resistant to apoptosis C. Cancer cells have more efficient DNA repair mechanism than normal cells. D. Only cancer cells are actively dividing E. They may lack key G2/M checkpoint controlsarrow_forward
- "In the cellular regulatory pathways that control cell growth and proliferation, the products of oncogenes are stimulatory components and the products of tumor suppressor genes are inhibitory components" is true or false.arrow_forwardWhich of the following are charcteristics you would expect of a circulating tumor cell that has undergone Epithelial-Mesenchymal Transition (select all that apply)? A. Increased N-cahedrin expression B. Increased resistance to apoptosis C. Loss of ability to secrete fibronectin D. High cytokeratin expression E. Elevated PDGF Receptor Expressionarrow_forwardChemotherapeutic agents can promote apoptosis in cancer cells by these mechanisms except; Group of answer choices Downregulating MCL1 expression Increasing BCL-2 expression Increased p53 expression Increased BIM (BH-3) expressionarrow_forward
- Which of the following is true of tumor suppressor genes? Group of answer choices a) If this gene is overactive, it becomes an oncogene b) If one of the alleles is mutated, there is usually little effect. Two inactivating mutations are usually required for loss of function (recessive mutation). c) If one copy is lost, the gene no longer functions (dominant mutation) d) Tumor suppressors genes usually cause mitosis or cell growth e) Tumor suppressor genes decrease apoptosisarrow_forwardPlease choose one of these choices A. Since protein A is embedded in the membrane., the mutation will be silent and not affect the cellular response. B. The molecule that normally binds to protein A will not enter the cell, thus no cellular response will occur. C. The molecule that normally binds to protein A will no longer attach, deactivating the cellular response. D. Production if activated molecule 1 will stop, bht production of activated molecules 2 and 3 will continue.arrow_forwardUnderstand how a cancer cell from a primary benign tumor is able to leave the primary benign tumor and enter the blood stream or lymph (migration), start to adhere and grow in a nearby environment like a blood vessel near an organ (invasion) and enter into a new organ to grow and form a secondary tumor ( extravasation). What proteins would be involved in these steps and what molecular changes in the ECM or basal lamina would need to occur as well as the cancer cell for this process to happen.arrow_forward
- Name the six fundamental properties of malignant tumours. Which of these properties are amenable to study in a cell culture model of cancer and why?arrow_forwardExplain the mechanism of Warburg effect and how it benefits cancer cells? With this guidearrow_forwardHow is apoptosis involved in cancer? Describe the role of apoptosis in cancer and identify what molecules are involved. Cite your references. asap.arrow_forward
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