cetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly. The activated receptor stimulates a G protein, which opens a K+ channel in the plasma membrane, as shown in Figure 1. Which of the following would enhance this effect of the acetylcholine? (a) (b) (c) (d) X Figure 1 addition of a high concentration of a non-hydrolyzable analog of GTP addition of a drug that prevents the a subunit from exchanging GDP for GTP mutations in the acetylcholine receptor that weaken the interaction between the receptor and acetylcholine mutations in the acetylcholine receptor that weaken the interaction between the receptor and the G protein

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter3: The Plasma Membrane And Membrane Potential
Section: Chapter Questions
Problem 2SQE: One of the important uses of the Nernst equation is in describing the flow of ions across plasma...
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3) Acetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly.
The activated receptor stimulates a G protein, which opens a K+ channel in the
plasma membrane, as shown in Figure 1. Which of the following would enhance
this effect of the acetylcholine?
(a)
(b)
(c)
(d)
Figure 1
addition of a high concentration of a non-hydrolyzable analog of GTP
addition of a drug that prevents the a subunit from exchanging GDP for
GTP
mutations in the acetylcholine receptor that weaken the interaction
between the receptor and acetylcholine
mutations in the acetylcholine receptor that weaken the interaction
between the receptor and the G protein
Transcribed Image Text:3) Acetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly. The activated receptor stimulates a G protein, which opens a K+ channel in the plasma membrane, as shown in Figure 1. Which of the following would enhance this effect of the acetylcholine? (a) (b) (c) (d) Figure 1 addition of a high concentration of a non-hydrolyzable analog of GTP addition of a drug that prevents the a subunit from exchanging GDP for GTP mutations in the acetylcholine receptor that weaken the interaction between the receptor and acetylcholine mutations in the acetylcholine receptor that weaken the interaction between the receptor and the G protein
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