4. A polypeptide comprised of 17 amino acid res-idues with the sequence on the right is ob-servedby spectroscopic methods to undergo transitionsfrom an a-helix conformation to a B-sheet as afunction of pH and concentration. The acetyl and carboxamide groups are attached covalently to deri-vatize the N- and C-terminal residues, respectively, to avoid charge effects of the end groups.CH3CO-ETATKAELLAKYEATHK-CONH2(а)amino acid residues.Write the sequence of this polypeptide with corresponding 3-letter abbreviations for the(b) At pH < 4 the polypeptide forms an a-helix. (i)the helix? and (ii)with respect to the positive and negative ends of the macrodipole?What is the direction of the macrodipole ofAre the charges on the N- and C-terminal residues stabilizing or de-stabilizing

Polypeptide: These are chains of amino acids with peptide bonds that connect them. Dehydration of…

CH3CO-ETATKAELLAKYEATHK-CONH2 4. A polypeptide comprised of 17 amino acid res- idues with the sequence on the right is ob-served by spectroscopic methods to undergo transitions from an a-helix conformation to a ß-sheet as a function of pH and concentration. The acetyl and carboxamide groups are attached covalently to deri- vatize the N- and C-terminal residues, respectively, to avoid charge effects of the end groups. (a) Write the sequence of this polypeptide with corresponding 3-letter abbreviations for the amino acid residues. (b) At pH ≤ 4 the polypeptide forms an a-helix. (i) What is the direction of the macrodipole of the helix? and (ii) Are the charges on the N- and C-terminal residues stabilizing or de-stabilizing with respect to the positive and negative ends of the macrodipole?

CH3CO-ETATKAELLAKYEATHK-CONH2 4. A polypeptide comprised of 17 amino acid res- idues with the sequence on the right is ob-served by spectroscopic methods to undergo transitions from an a-helix conformation to a ß-sheet as a function of pH and concentration. The acetyl and carboxamide groups are attached covalently to deri- vatize the N- and C-terminal residues, respectively, to avoid charge effects of the end groups. (a) Write the sequence of this polypeptide with corresponding 3-letter abbreviations for the amino acid residues. (b) At pH ≤ 4 the polypeptide forms an a-helix. (i) What is the direction of the macrodipole of the helix? and (ii) Are the charges on the N- and C-terminal residues stabilizing or de-stabilizing with respect to the positive and negative ends of the macrodipole?

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter3: Biological Molecules: The Carbon Compounds Of Life

Section: Chapter Questions

Problem 8TYK: The first and major effect in denaturation of proteins is that: a. peptide bonds break. b. helices...

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