Please help with 1a) 1b) and 1c) ! If cant do all, then as much as you can, thank you! Question #11A. The pyruvate dehydrogenase complex is heavily regulated as the nexus between glycolysis and the citric acid cycle:(i)NADH (positive regulator || negative regulator)(ii)Fatty Acids (positive regulator || negative regulator)NH₂1B. In the pyruvate dehydrogenase complex the cofactor thiamine pyrophosphate(TPP) is used to decarboxylate pyruvate. Provide a drawing that shows the chemicalmechanism of decarboxylation. [Show electron pushing and relevant resonancestructures. You do not need to show the entire mechanism catalyzed by PDHC.OHP-OOHP-OH1C. What happens next to the pyruvate fragment that is attached to TPP? What cofactor oxidation state of the E2-centered redox cofactor is required to successfully transfer a pyruvate-derived hydroxyethyl fragment from the E₁-boundTPP cofactor onto the E₂ domain? (you can state this in words, no arrow pushing required)

Under aerobic condition, the pyruvate molecule which is produced as the end product of the…

Answered: Please help with 1a) 1b) and 1c) ! If…

Science

Biochemistry

Please help with 1a) 1b) and 1c) ! If cant do all, then as much as you can, thank you!

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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