1 A 59 kg male received 2 mg/kg of an antibiotic orally.The following plasma concentration versus time date isobtained. Assume that the drug follows one compartmentopen model and is completely absorbed.- Calculate the following:1) Estimation rate constant k and biological half-life t2.2) Absorption rate constant k, and absorption half-life.3) Volume of distribution, V..4) tmax, and Cmax -5) AUC. Time (hr)Cp (mcg/ml)0.252.20.503.80.755.01.05.81.56.82.07.1257.13.06.94.06.26.04.88.03.512.01.918.00.824.00.3

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compartment

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter16: Adult And Pediatric Dosages Based On Body Surface Area

Section: Chapter Questions

Problem 5.3P

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Question

1 A 59 kg male received 2 mg/kg of an antibiotic orally.
The following plasma concentration versus time date is
obtained. Assume that the drug follows one compartment
open model and is completely absorbed.
- Calculate the following:
1) Estimation rate constant k and biological half-life t2.
2) Absorption rate constant k, and absorption half-life.
3) Volume of distribution, V..
4) tmax, and Cmax -
5) AUC.

Time (hr)
Cp (mcg/ml)
0.25
2.2
0.50
3.8
0.75
5.0
1.0
5.8
1.5
6.8
2.0
7.1
25
7.1
3.0
6.9
4.0
6.2
6.0
4.8
8.0
3.5
12.0
1.9
18.0
0.8
24.0
0.3

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