Consider the following genotype: ● ● ● (P1) A/a BC/bc_D/d E/e FgH/fGh X (P2) A/a BC/bc D/d E/e fgh/fGh There are 10 m.u. between B and C genes There are 5 mu, between F and G genes There are 10 m.u. between G and H genes
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- A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?As it turned out, one of the tallest Potsdam Guards had an unquenchable attraction to short women. During his tenure as guard, he had numerous clandestine affairs. In each case, children resulted. Subsequently, some of the childrenwho had no way of knowing that they were relatedmarried and had children of their own. Assume that two pairs of genes determine height. The genotype of the 7-foot-tall Potsdam Guard was A9A9B9B9, and the genotype of all of his 5-foot clandestine lovers was AABB. An A9 or B9 allele in the offspring each adds 6 inches to the base height of 5 feet conferred by the AABB genotype. a. What were the genotypes and phenotypes of all the F1 children? b. Diagram the cross between the F1 offspring, and give all possible genotypes and phenotypes of the F2 progenyDuchenne muscular dystrophy is sex linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brotherhas Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’sdisease, what is the probability that you have receivedthe allele?c. If your father’s brother had the disease, what is theprobability that you have received the allele?
- We have dealt mainly with only two genes, but the sameprinciples hold for more than two genes. Consider thefollowing cross:A/a ; B/b ; C/c ; D/d ; E/e × a/a ; B/b ; c/c ; D/d ; e/ea. What proportion of progeny will phenotypicallyresemble (1) the first parent, (2) the second parent,(3) either parent, and (4) neither parent?b. What proportion of progeny will be genotypically thesame as (1) the first parent, (2) the second parent,(3) either parent, and (4) neither parent?Assume independent assortment.An individual heterozygous for four genes, A/a • B/b •C/c • D/d, is testcrossed with a/a • b/b • c/c • d/d, and 1000progeny are classified by the gametic contribution ofthe heterozygous parent as follows:a • B • C • D 42A • b • c • d 43A • B • C • d 140a • b • c • D 145a • B • c • D 6A • b • C • d 9A • B • c • d 305a • b • C • D 310a. Which genes are linked?b. If two pure-breeding lines had been crossed toproduce the heterozygous individual, what would theirgenotypes have been?c. Draw a linkage map of the linked genes, showing theorder and the distances in map units.d. Calculate an interference value, if appropriate. A geneticist mapping the genes A, B, C, D, and E makestwo 3-point testcrosses. The first cross of pure lines isA/A ⋅ B/B ⋅ C/C ⋅ D/D ⋅ E/E × a/a ⋅ b/b ⋅ C/C ⋅ d/d ⋅ E/EThe geneticist crosses the F1 with a recessive tester andclassifies the progeny by the gametic contribution ofthe F1:A ⋅ B ⋅ C ⋅ D ⋅ E 316a ⋅ b ⋅ C ⋅ d ⋅ E 314A ⋅ B ⋅ C ⋅ d ⋅ E 31a ⋅ b ⋅ C ⋅ D ⋅ E 39A ⋅ b ⋅ C ⋅ d ⋅ E 130a ⋅ B ⋅ C ⋅ D ⋅ E 140A ⋅ b ⋅ C ⋅ D ⋅ E 17a ⋅ B ⋅ C ⋅ d ⋅ E 131000The second cross of pure lines is A/A • B/B • C/C • D/D •E/E × a/a • B/B • c/c • D/D • e/e.The geneticist crosses the F1 from this cross with arecessive tester and obtainsA ⋅ B ⋅ C ⋅ D ⋅ E 243a ⋅ B ⋅ c ⋅ D ⋅ e 237A ⋅ B ⋅ c ⋅ D ⋅ e 62a ⋅ B ⋅ C ⋅ D ⋅ E 58A ⋅ B ⋅ C ⋅ D ⋅ e 155a ⋅ B ⋅ c ⋅ D ⋅ E 165a ⋅ B ⋅ C ⋅ D ⋅ e 46A ⋅ B ⋅ c ⋅ D ⋅ E 341000The geneticist also knows that genes D and E assortindependently.a. Draw a map of these genes, showing distances inmap units wherever possible.b. Is there any evidence of interference?
- Consider the following cross examining four gene in two parental line: Parent 1: A/a; B/B; D/d; E/e Parent 2: A/a; B/b; d/d; e/e Assuming independent assortment for the four genes, what fraction of progeny will be phenotypically identical to either parent 1 or parent 2? (Hint: first figure out the fraction of progeny that resembles parent 1 and parent 2 separately, then get the overall fraction.) 3/8 3/4 3/16 1/16 9/16Which of the following statements illustrates codominance? Select one: a. Red flowers crossed with white flowers produce pink flowers. b. Individuals who are heterozygous for the sickle cell anemia allele are more resistant to malaria. c. Two parents with blood types A and B can have children with blood type O. d. Grey heterozygous chickens have black and white feathers.Consider three genes L, U, and W, for which the count of F2 phenotypes after a 3-point cross is as follows: Phenotype F2 count: L U w 19 L u W 1 l u W 21 L U W 33 l U W 274 l u w 41 l U w 2 L u w 259 Which of the following statements about genes L, U, and W are TRUE? (may be more than one correct ans) A. L, U, and W are each on a different chromosome B. Only U and L are on the same chromosome C. Only U and W are on the same chromosome D. Only W and L are on the same chromosome E. L, U, and W are all on the same chromosome
- Using the same information listed above for hair and eye color, (E = dominant brown eyes with e = recessive blue eyes; R = dominant brown hair and r = recessive blond hair), if the mom was heterozygous for both eye color and hair color what would her genotype be? a. EERR b. eerr c. EeRr What would be the 4 possible gametes the heterozygous mom could contribute? a. RE, Re, rE, re b. Rr, Ee, RE, re c. RR, rr, EE, eeE. W. Lindstrom crossed two corn plants with green seedlings and obtained the following progeny: 3583 green seedlings, 853 virescentwhite seedlings, and 260 yellow seedlings . Q. Give the genotypes for the green, virescent-white, and yellow progeny.When a pure bred red four o.clock flower (RR) is crossed to a pure bred four o'clock white flowers (WW) resulted to four (4) pink four o'clock flowers, Which of the following is the genotype of the pink flower? a. RR b. WW c. RW d. red and white