Considering the metabolic disorder "Ethanol Sensitivity".Which of the following therapeutic approaches could result in improvement for an individual with this disorder?(Select 2 answers)O Pharmacological competitive inhibition of Ethanol DehydrogenaseO Pharmacological alloseteric inhibition of cytosolic acetylaldehyde dehydrogenaseO Pharmacological activation of cytosolic aldehyde dehydrogenaseO Pharmacological uncompetitive inhibition of mitochondrial acetylaldehyde dehydrogenase

Ethanol sensitivity is characterized by an immediate negative reaction after alcohol intake. The…

Answered: Considering the metabolic disorder…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter23: Fatty Acid Catabolism

Section: Chapter Questions

Problem 17P

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Indicate what will happen ( increase, decrease or no effect) tothe activity of the enzyme or rate of the metabolic pathway in the given conditions a. release of glucagon in the blood to the activity of carnitine acyl transferase 1 b. high malonyl CoA to the activity of carnitine acyl transferase I C. Epinephrine to the activity og glycogen synthase d. high citrate to the activity of acetyl CoA carboxylase e. high acetyl CoA to ketogenesis
Propionic acidemia has a relatively high prevalence in South Africa, among both black and white families. This fatal disease is often diagnosed by the elevated presence of propionyl carnitine, propionylglycine and methyl citrate in blood and urine. Discuss the metabolism involved and origin of these markers.
Indicate what will happen (increase, decrease or no effect) to the activity of enzyme or rate of the metabolic pathway given the following conditions: 1. release of glucagon in the blood to the activity of carnitine acyl transferase 1 2. phosphorylation of acetyl CoA carboxylase 3. low [carbon dioxide]/[oxygen gas] ratio to the oxygenase activity of RuBisCO
Predict which one of the five steps of the α-ketoglutarate dehydrogenase complex reaction is metabolically irreversible under physiological conditions and explain why.
One of the consequences of ethanol addiction is fattyliver disease, an illness in which liver cells accumulatetriacylglycerols, the esters derived from glycerol and fattyacids. Ethanol is oxidized in the cytoplasm of liver cells byalcohol dehydrogenase and aldehyde dehydrogenase to yieldacetate and 2 NADH. Acetate is then transported into themitochondrion, where it is converted to acetyl-CoA andmetabolized by the citric acid cycle. When alcohol is consumed in excessive quantities, the resulting high levels ofNADH cause metabolic abnormalities, one of which is highlevels of fatty acid synthesis. Fatty acid synthesis, also acytoplasmic process, uses acetyl-CoA as a substrate andNADPH as a reducing agent. Determine how a high level ofcytoplasmic NADH provides a source of NADPH for fattyacid synthesis.
Discuss the metabolic control for HMG CoA reductase synthesis and activity
Choose all the enzymes or enzyme systems of the citric acid cycle that could be classified as oxidoreductases. (Select all that apply.) succinate dehydrogenase aconitase isocitrate dehydrogenase α-ketoglutarate dehydrogenase complex citrate synthase fumarase malate dehydrogenase
Alpha-ketoglutarate dehydrogenase exhibits feedback inhibition by
Predict which one of the five steps of the a-ketoglutarate dehydrogenase complex reaction is metabolically irreversible under physiological conditions and explain why.
Von Gierke’s disease is also known as glycogen storage disease type I. Patients with von Gierke’s disease lackglucose 6-phosphatase activity. Two prominent symptoms of this disorder are fasting hypoglycemia and lactic acidosis (elevated lactate levels in the blood), especially during strenuous exercise. Explain why these symptoms occur. What chemical reaction does this enzyme catalyze? Which pathways involve this enzyme? Lacking thisthe enzyme will cause impairment of which pathways?• Pls consider what pathways are affected by Von Gierke’s disease. Include in your explanation involving Cori’s cycle. can you please do not write by your hand? I mean computer if you can. thank you
State the steps of ketone body formation, starting with two acetyl CoA. Please make sure to state all the enzymes and co-factors for each reaction.
A. What would be the effect of barbiturate abuse on oxidative phosphorylation ? B. What is the biochemical basis of carbon monoxide fatility?

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