Please post answer with an explanation, thank you! 1. The compound carboxymethyl-CoA (shown below) is a competitive inhibitor of citrate synthase and is a proposed transition state analog. Propose a structure for the reaction intermediate derived from acetyl-COA in the rate-limiting step of the reaction, just prior to its reaction with oxaloacetate. но CoA-S-CH,-c Carboxymethyl-CoA (transition state analog)

Please post answer with an explanation, thank you! 1. The compound carboxymethyl-CoA (shown below) is a competitive inhibitor of citrate synthase and is a proposed transition state analog. Propose a structure for the reaction intermediate derived from acetyl-COA in the rate-limiting step of the reaction, just prior to its reaction with oxaloacetate. но CoA-S-CH,-c Carboxymethyl-CoA (transition state analog)

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 4P: Understanding the Mechanism of the -Ketoglutarate Dehydrogenase Reaction tshe first step of the...

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Need help, please. Given that the enzyme pyruvate carboxylase converts Pyruvate into Oxaloacetate and this is an anapleurotic reaction. In the liver, what is most of the OAA converted into under these conditions? Please explain. 1. When blood glucose levels are low and the energy charge in the cell is high. 2. When mitochondrial acetyl-CoA levels are high and the energy charge is low.
Please state if the statements are true or false.1. When fructose forms its Haworth projection, it usually assumes a pyranose structure2. The conversion of 1 mole aplha-ketoglutarate to 1 mole succinyl CoA produces 2 moles of carbon dioxide
Instructions. Given each set of information which may include common name(s) and the reaction catalyzed, you are required to identify the main class of the specific enzyme described. Name: citryl-CoA synthetase Reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA Name: D-xylulose reductase Reaction: xylitol + NAD+ = D-xylulose + NADH + H+ Name: cellobiose phosphorylase Reaction: cellobiose phosphate = α-D-glucose 1-phosphate + D-glucose Name: carbonic anhydrase Reaction: H2CO3 = CO2 + H2O Other info: The enzyme catalyzes the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. Name: pantoate activating enzyme Reaction: ATP + (R)-pantoate = AMP + diphosphate + (R)-pantothenate.
Please please help me with these, thank you so muchshow the de novo synthesis of capric acid and which pathways produce NADPH? How is acetyl coA carboxylase being regulated?
Consider docosanoic acid C12H43CO2H a. Label the alpha and beta Carbons. Show the beta-oxidation in an EXPANDED structure. b. Draw each acyl CoA derived from this fatty acid. c. How many acetyl Co A molecules are formed by complete beta-oxidation? d. How many cycles of beta-oxidation are needed for complete oxidation? e. How many molecules of ATP are formed from the complete catabolism of this fatty acid? Show the complete computation. f. How many moles of ATP per gram of fatty acid is formed from the complete catabolism of the given fatty acid? g. What is the molar mass of the given fatty acid? Solution: Show here the complete computations, [from a to e]
For myristic acid, C 13H 27CO 2H: (a) How many molecules of acetyl CoA are formed from complete β-oxidation? (b) How many cycles of β-oxidation are needed for complete oxidation?
Extending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.
Understanding the Mechanism of the -Ketoglutarate Dehydrogenase Reaction tshe first step of the -Ketoglutarate dehydrogenase reaction involves decarboxylation of the substrate and leaves a covalent TPP intermediate. Write a reasonable mechanism for this reaction.
Instructions. Given each set of information which may include common name(s) and the reaction catalyzed, you are required to identify the main class of the specific enzyme described. _____________________ Name: alkaline phosphatase Reaction: a phosphate monoester + H2O = an alcohol + phosphate _____________________ Reaction: L-threonine = D-threonine. Other information: Inverts both chiral centers, a racemase. _____________________ Name: glycine-N-acylase Reaction: acyl-COA + glycine = CoA + N-acylglycine _____________________ Name: lysine decarboxylase Reaction: L-lysine = cadaverine + CO2 _____________________ Name: methanol dehydrogenase Reaction: methanol + NAD+ = formaldehyde + NADH + H+ _____________________ Name: citryl-CoA synthetase Reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA _____________________ Name: D-xylulose reductase Reaction: xylitol + NAD+ = D-xylulose + NADH + H+ _____________________ Name: cellobiose phosphorylase Reaction:…
Instructions. Given each set of information which may include common name(s) and the reaction catalyzed, you are required to identify the main class of the specific enzyme described. _____________________ Name: alkaline phosphatase Reaction: a phosphate monoester + H2O = an alcohol + phosphate _____________________ Reaction: L-threonine = D-threonine. Other information: Inverts both chiral centers, a racemase. _____________________ Name: glycine-N-acylase Reaction: acyl-COA + glycine = CoA + N-acylglycine _____________________ Name: lysine decarboxylase Reaction: L-lysine = cadaverine + CO2 _____________________ Name: methanol dehydrogenase Reaction: methanol + NAD+ = formaldehyde + NADH + H+
CHOOSE THE CORRECT LETTER 1.What are the B-oxidation products of lauric acid (C12H2402), a major component of coconut oil?A.6 acetyl-CoA, 6 NADH, 6 FADH2B. 6 acetyl-CoA, 5 NADH, 5 FADH2C. 5 acetyl-CoA, 6 NADH, 6 FADH2D. 5 acetyl-CoA, 5 NADH, 5 FADH2 2.What is the mechanism of ATP synthesis in glycolysis?A. substrate level phosphorylationB. reductionC. oxidationD. oxidative phosphorylation 3.Which of the following enzymes need ATP as a substrate in the reaction?A.phosphoglycerate kinaseB. phosphofructokinaseC. pyruvate kinaseD.glyceraldehyde-3-phosphate dehydrogenase
Considering the fatty acids: (a) Arachidic acid (C20H40O2); molar mass = 312.5 g/mol) (b) Palmitoleic acid (C16H30O2); molar mass = 256.4 g/mol). How many cycles of β -oxidation are needed for complete oxidation? How many molecules of acetyl CoA are formed from its complete catabolism? How can you calculate the number of molecules (moles) of ATP formed (net) by the complete catabolism of each fatty acid? and the number of moles of ATP formed per gram of each fatty acid metabolized??