Discuss the role of E286 in the proton transfer carried out by cytochrome c oxidase.  What are the D- and K-pathways? What is the fate of the protons from these two pathways? What is the role of E286?

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 24P: Based on your knowledge of the structure of NAD+ and an assumption that coenzyme dissociation is the...
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Discuss the role of E286 in the proton transfer carried out by cytochrome c oxidase. 

  1. What are the D- and K-pathways?
  2. What is the fate of the protons from these two pathways?
  3. What is the role of E286?
  4. What three mechanisms contribute to the movement of the protons along these pathways?
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