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Draw and explain the conceptual pathway of mechanism, transport and excretion of drugs
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- What are the different sources of drugs? Give an drug from each of these example of a sourcesWhich of the following statements concerning drug delivery system is INCORRECT?* A.Drugs with good aqueous solubility are good for controlled release formulation. B.The delay-released form is also called extended release form. C.Absorption rate is higher in compressed tablets than that in capsules. D.Drug core with polymer membrane coating belongs to diffusion sustained system. E.Disintegration and dissolution can occur at the same time.In your own understanding, which among the routes/forms of drug administration above has the most rapid absorption? Has the slowest absorption? Explain your answer.
- List all the possible modes of entry of the drug to the target cell membranes.▪ A patient arrives at the ER complaining of seizures. The patient is taking phenytoin as prescribed which has a therapeutic range of 10-20 ug/mL. You order the SDC and find it is 8 ug/mL at steady state. This is an indication that A) dose needs to be increased. The dose needs to be individualized. ▪ B) The patient is noncompliant.The mechanism of acquired drug resistance that would prohibit the drug molecule from entering a target cell would be considered: Use of alternate metabolic pathway Drug inactivation Activation of drug pumps Decreased permeability Change in drug binding site