Draw the mechanism for the serine protease catalyzed hydrolysis of a diglycine peptide.

Q: Explain how the g-glutamyl cycle acts to transport aminoacids across a membrane. How does the…

A: Gamma-Glutamyl cycle is mainly a glutathione salvage pathway. It is an essential pathway for the…

Q: Draw in detail the pathway of de novo synthesis of deoxythymidine phosphate and provide a brief…

A: First carbamoyl phosphate is synthesized , which then enters the de-novo synthesis pathway for…

Q: Describe results that could be obtained from ribosomeprofiling that would indicate the existence of…

A: Ribosome profiling is a technique which is based on deep sequencing of ribosome protected fragments…

Q: Illustrate the mechanism of action of ysozyme.

A: INTRODUCTION In many animal cells, lysosomes are found. Circular vesicles with hydrolytic enzymes…

Q: Compare and contrast cotranslational import of polypeptides with posttranslational import of…

A: Import of polypeptides across the membrane bilayer refers to the translocation process. The…

Q: Define innexin-like

A: The cells are the primary unit of life. Based on the number of cells an organism may be unicellular…

Q: TPCK and TLCK are irreversible inhibitors of serine proteases. One ofthese inhibits trypsin and the…

A: Both are irreversible inhibitors.

Q: Propose a role for the positively charged guanidinium nitrogen atom in the cleavage of…

A: The urea cycle is a series of biochemical reactions which involve the formation of urea (NH2)2C0…

Q: The catalytic mechanism of bovine pancreatic RNase A relies upon acid-base catalysis involving the…

A: Bovine pancreatic RNase is a nuclease Enzyme that catalyses the cleavage of RNA. The protein…

Q: What advantages are there for synthesizing an inactive protein that must subsequently be activated…

A: When the proteins are synthesized into naive polypeptide then these are transferred to the…

Q: From the result shown, what might be the histidine biosynthetic pathway (the order of enzymes)?

A: Histidine biosynthesis is an ancient metabolic partway present in bacteria, archaea, lower…

Q: 10. (a) Provide the scheme of Merrifield peptide synthesis with suitable example. (b) Describe the…

A: Amino acids are biomolecules that are comprised of two functional groups, these are an amino group…

Q: The enzyme chymotrypsin, catalyses the hydrolysis of nitrophenyl acetate and pther acyl esters. Name…

A: Chymotrypsin is a digestive enzyme belonging to a super family of enzymes called serine proteases.…

Q: by namlng the amlno aclds from the N-terminal to the C- terminal. Use the long name, the 3-letter…

A: Bradykinin is a nonapeptide that means it contains 9 amino acid. At low pH, a peptide remain full…

Q: Snake venom contains many hydrolase enzymes, including several serine proteases. One such protease…

A: Enzymes are highly specialized proteins that have extraordinary catalytic power, greater than that…

Q: A)How could the sequence of Ala-Met-Thr be distinguished from that of Thr-Ala-Met by tandem ESI-MS?…

A: A polypeptide is a polymer of amino acids. The sequence of a polypeptide is written from the…

Q: the key features between glycosaminoglycan-binding proteins and lectins?

A: Glycosaminoglycans (GAGs) are mucopolysaccharides containing a large number of disaccharide units…

Q: Describe the two sequential reactions that occur in the activesite of aminoacyl-tRNA synthetases.

A: This two-step reaction of aminoacyl-tRNA synthetases occurs during the process of protein synthesis.

Q: Write out a mechanism for the serine triad hydrolysis ofglycylglycine.

A: The dipeptide unit of glycine is glycylglycine. Serine proteases are a group of enzymes that contain…

Q: Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the…

A: Nucleotides are ubiquitous as they are involved in majority of biochemical reactions. All of the…

Q: Consider, for example, that a particular serine residue is phosphorylated to activate the protein.…

A: Phosphorylation can either activate or deactivate a protein. Phosphomimetics replaces amino acids in…

Q: Explain how genetic mutations of phosphoribosyl pyrophosphate synthetase causing superactivity lead…

A: The overproduction and buildup of uric acid (a waste product of normal chemical processes) in the…

Q: A mutation results in the change of Ser to Asp in the active site of chymotrypsin. Most likely, the…

A: >serine protease Catalyzes the hydrolysis of peptide bonds, on the carboxyl side of bulky…

Q: Consider protein degradation in the absence of ubiquitinylation. Is the process likely to be more or…

A: Ubiquitinylaton is the process of the addition of a protein called ubiquitin to the substrate…

Q: What is denaturation? Give examples. What are the factors that affects the proteir synthesis?

A: Proteins are defined as an unbranched polymers which are made up of 22 amino acids. They are usually…

Q: Is amino acid activation energetically favored? Why or why not?

A: Introduction: Amino acid activation is done at the initiation step of the translation. This step is…

Q: SH HN H e. PEPTIDE ACWNEG

A: Chymotrypsin is a proteolytic enzyme that is produced by the pancreas an it  is used in the small…

Q: Trypsin cleaves proteins on the carboxyl side of lysine. Trypsin inhibitor has a lysine residue, and…

A: Introduction: An enzyme is the catalysts that increase the rate of reaction without undergoing any…

Q: The catalytic mechanism of bovine pancreatic RNase A relies upon acid-base catalysis involving the…

A: Bovine pancreatic RNase A catalyzes the hydrolysis of phosphodiester bond of the RNA.

Q: Describe the path for the synthesis of TTP from UTP.

A: Nucleic acids are biomolecules that form the building blocks for DNA and RNA molecules. They contain…

Q: In the serine protease triad, the proximity of an aspartate carboxylate group of histidine raises…

A: Serine protease is a class of proteolytic enzymes in which serine residue is present at the active…

Q: Provide the mechanism for step 2 of the biological formation of geranyl diphosphate (A') are…

A: Coupling of two Isopentenyl pyrophosphate molecules gives geranyl pyrophosphate or geranyl…

Q: Describe how a protein is targeted for degradation in a proteasome.

A: Proteolysis, or protein degradation is a bunch of cycles that bring about the hydrolysis of at least…

Q: Why is TLCK specific for trypsin and TPCK is specific for chymotrypsin?

A: TLCK stands for Tosyl Lysinyl Chloromethyl Ketone and TPCK stands for Tosyl Phenyl Chloromethyl…

Q: Which of the following is an example of an unacceptable missense?

A: Amino acids are organic compounds which contain amino group, carboxyl group and functional groups…

Q: Can you answer all the parts to this question please A. Where does a low barrier hydrogen bond…

A: Protease is an enzyme that is observed in both prokaryotes and eukaryotes and is involved in…

Q: The biosynthetic pathway for the two amino acides E and H is shown schematically in the Figure…

A: Feedback inhibition is a cellular control mechanism in which an enzyme's activity is inhibited by…

Q: What is the purpose of the NaKATPase in a mammalian cell?

A: A phospholipid bilayer integrated with proteins forms the plasma membrane. It provides a durable…

Q: Show the peptides that would result from cleavage by the indicated reagent: a.…

A: A peptide is a long chain of amino acids connected together via a peptide bond. Different peptides…

Q: SH NH2 NH2 но NH2 C. H,N

A: Peptides or proteins are composed of twenty standard amino acids. These twenty standard amino acids…

Q: Why Phenylmethylsulfonyl fluoride (PMSF, shown in Fig.) does not inhibit aspartate protease as…

A: The chemical compounds which are used to protect the proteins from the digestive function of the…

Q: r the conversion of Trypsinogen into Trypsin, Write the total number of amino acids should be…

A: The answer is given below,

Q: Describe the importance of ubiquitin-dependent degradation of soluble proteins.

A: Thousands of distinct proteins are found in all living cells, each of which performs a specific…

Q: Glucose has been found to react nonenzymatically with hemoglobin, through Schiff base formation…

A: Glucose :  It is a simple carbohydrate or sugar. It is one of several kinds of sugars. It is…

Q: Explain how the pKa for histidine 57 is important to its role in the mechanism of chymotrypsin…

A: Chymotrypsin is a digestive enzyme found in pancreatic juice that conducts proteolysis, or the…