During fatty acid biosynthesis, is it correct that the product detaches from fatty acid synthase complex when the chain length is 16 carbons?
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During fatty acid biosynthesis, is it correct that the product detaches from fatty acid synthase complex when the chain length is 16 carbons?
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- Using the ActiveModel for aldose reductase, describe the structure of the TIM barrel motif and the structure and location of the active site.Is the statement during fatty acid biosynthesis, the product detaches from fatty acid synthase complex when the chain length is 16 carbons, wrong or right?The second step during elongation of fatty acid chain is catalyzed by B-ketoacyl reducatse. In which 2 ways is this reaction different from the corresponding reaction in fatty acid degradation?
- What would be the effect on fatty acid synthesis of a mutation in ATPcitrate lyase that reduces the enzyme’s activity? Explain.Explain why people with a hereditary deficiency of carnitine acyltransferase II have muscle weakness. Why are the symptoms more severe during fasting?Consider the complete oxidation of a mixed TAG containing the following fatty acid residues:At carbon 1: cerotic acidAt carbon 2: heptadecanoic acidAt carbon 3: palmitoleic acid Draw the structure of the mixed TAG.
- Define beta-oxidation of fatty acids? Describe in detail three different steps of beta-oxidation of FAs.hat enzymes are required for the synthesis of a glycogen particle starting from glucose 6-phosphate?If G6P is labeled at its C2 position, where will the label appear in the products of the pentose phosphate pathway?
- Mechanistically, how does NADPH facilitate the removal of an oxygen atom from intermediates in fatty acid synthesis?We have stated that fatty acids cannot yield a net gain in carbohydrates in organisms that lack a glyoxalate pathway. Why can odd-chain fatty acids be thought to break this rule to a small extent?How would chymotrypsin's catalytic triad be affected by extremely low and extremely high pH values (assuming the rest of the protein remains intact)?
