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- Understanding the Mechanism of Hemolytic Anemia Genetic defects in glycolytic enzymes can have serious consequences for humans For example, defects in the gene for pyruvate kinase can result in a condition known as hemolytic anemia. Consult a reference to learn about hemolytic anemia, and discuss why such genetic defects lead to this condition.GTP or ATP is produced during the conversion of isocitrate into ketoglutarate succinyl CoA into succinate fumarate into malate malate into oxaloacetateyou follow a carbohydrate-free diet, certain metabolic problems occur. Describe glucogenesis and the problems that may arise from this prolonged glucogenesis state.
- In the absence of food consumption, the rate of gluconeogenesis (GNG) tends to increase. Explain why this occurs and describe the range of substrates for GNG as fasting continues beyond 18 hours. asapNonalcoholic fatty liver disease is thought to be exacerbated by a diet heavy in sugar. Explain?In the fasted state, FADH2 and NADH for oxidative phosphorylation are mainly provided by fatty acid oxidation. Explain how fatty acids are mobilised from adipose tissue by the action of glucagon.
- Fatty acids appear to stimulate insulin secretion to a much greater extent when glucose is also present. Why is this significant?Individuals with Pompe disease lack the lysosomal _______. a. Glycogen phosphorylase b. Amylo-α(1→6)-glucosidase c. α(1→4)-glucosidase d. Glucose-6-phosphataseDefine the following terms:a. b-oxidationb. carnitinec. ketogenesisd. ketone bodiese. ketosis
- c) Cooperation between glycolysis and gluconeogenesis is important to ensure the glucose-subjected energy demands of specific cells are met. Explain this statement.describe a ketogenic diet. what are the pros and cons of such a diet. how is ketosis related to diabetes mellitus?Indicate whether each of the following B vitamins is involved (as a cofactor) in β-oxidation pathway, ketogenesis, lipogenesis, or conversion of ketone bodies to acetyl CoA. There may be more than one correct response or no correct response for a particular B vitamin.
