Eugene Eisen selected for increased 12-day litter weight (total weight of a litter of offspring 12 days after birth) in a population of mice (E. J. Eisen. 1972. Genetics 72:129–142). The 12-day litter weight of the population steadily increased, but then leveled off after about 17 generations. At generation 17, Eisen took one family of mice from the selected population and reversed the selection procedure: in this group, he selected for decreased 12-day litter weight. This group immediately responded to the reversed selection: the 12-day litter weight dropped 4.8 g within 1 generation and dropped 7.3 g after 5 generations. On the basis of the results of the reverse selection, what is the most likely explanation for the leveling off of 12-day litter weight in the original population?

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter19: Population Genetics And Human Evolution
Section: Chapter Questions
Problem 8QP: How Can We Measure Allele Frequencies in Populations? In a population where the females have the...
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Eugene Eisen selected for increased 12-day litter weight (total weight
of a litter of offspring 12 days after birth) in a population of mice (E. J.
Eisen. 1972. Genetics 72:129–142). The 12-day litter weight of the
population steadily increased, but then leveled off after about 17
generations. At generation 17, Eisen took one family of mice from the
selected population and reversed the selection procedure: in this group,
he selected for decreased 12-day litter weight. This group immediately
responded to the reversed selection: the 12-day litter weight dropped 4.8
g within 1 generation and dropped 7.3 g after 5 generations. On the basis
of the results of the reverse selection, what is the most likely explanation
for the leveling off of 12-day litter weight in the original population?

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