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Define about this- Cancer Cells Contain Genetic
Defects Affecting Genomic Stability ?
Step by step
Solved in 2 steps
- Define the Genomic Instability in cancer cells ? What is leads to ?There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA repair/stability genes. Distinguish between these three groups, then indicate which you think RB1 belongs to.There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA stability/repair genes. Define each of these categories and indicate which one you think the RB1 gene belongs to and why.
- The human genes that convey a susceptibility to hereditary nonpolyposis colorectal cancer aregenes coding proteins involved in which DNA repair mechanism?Genetic instability in the form of point mutations, chromosome rearrangements, andepigenetic changes needs to be maximal to allow the development of cancer.(a) With diagrams explain:(i) point mutations (ii) chromosome rearrangement (iii) epigenetic changesWhy is it important to model cancer through the generation of induced pluripotent stem cells ? Explain in detail the main findings.
- Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic changes needs to be maximal to allow the development of cancer. (a) With diagrams explain, chromosome rearrangementCharacterize the differences between tumor cells and normal cells in terms of the following properties. In cancer cells, how might each of these properties contribute to tumor progression? a) contact inhibition b) autocrine stimulation c) apoptosis d) senescence due to telomere shortening e) genomic stability f) angiogenises g) metastasisExplain the molecular mechanisms of cancers caused by a P53 gene mutation.
- Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please list item by item. Explain in detail the main findings.Explain why p53 is mutated in the vast majority of human cancers.Explain how telomerase expression contributes to theimmortality of cancer cells