Explain the rationale of dissolution of drugs according to pH? What is the pH of gastric fluid? What about the intestinal fluid?
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- Explain the rationale of dissolution of drugs according to pH?
- What is the pH of gastric fluid? What about the intestinal fluid?
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- The level of ketones should be low or absent in MCAD patients?Which of the following types of drugs will have maximum oral bioavailability?A. Drugs with high first-pass metabolism.B. Highly hydrophilic drugs.C. Largely hydrophobic, yet soluble in aqueous solutions.D. Chemically unstable drugs.E. Drugs that are P-glycoprotein substrates.What are ketone bodies? How are they formed? What makes carboxylic acids acidic? Define the following terms and give examples of eacha) Analgesicb) Antipyretic
- Give an example of N-dealkylation and oxidative deamination over the active molecule of a drug and indicate which type of metabolization they are.Explain why body fluids pH can affect drug absorption and distribution.If the daily requirement for Vitamin C is 75 mg, how many ml of the juice or Vitamin C tablets would be recommended as a daily intake?
- For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be used to make this drug more bioavailable after oral administration? This under Bipharmaceurics and Pharmacokinetics subject1.) How can these physiological factors listed below affect drug effect? Explain each. - diurnal rhythm - acid - base balance - hydration - electrolyte balance 2.)1.) How can these pathological factors listed below affect drug effect? Explain each. - Gi disorders - Vascular disorders - Liver dysfunction - Kidney dysfuntionWhat is the corresponding schedule for each of these drugs? a. Codeine at concentration of 10mg/mL (oral liquid) b. Codeine at concentration of 2mg/mL (orgal liquide)
- This drug has the highest incidence of postanesthetic nausea and vomiting. a. Sevoflurane.?????????? b. Thiopental c. Nitrous oxide d. Halothane e. Ketamine. f. PropofolWhat are the benefits of water, electrolytes and buffer systems on oral health and disease?Why do people use crack cocaine? What are the major toxicity caused by the use of high doses of this stimulant?
