Considering the evidence that led Krebs to propose a cyclic pathway for oxidation of pyruvate, discuss the type of experimental evidence that might have led to realization of the cycdic nature of the glyoxy- late pathway.
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- Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved residues in slightly different positions can change the catalytic rate of reaction.Understanding the Mechanism of the HMC-CoA Synthase Reaction Write a suitable mechanism for the HMG-CoA synthase reaction. What is the chemistry that drives this condensation reaction?Extending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.
- The Reactions and Meehanisms of the Leloir Pathway Write the reactions that permit galactose to be utilized in glycolysis. Write a suitable mechanism, tor one of these reactions.Considering the evidence that led Krebs to propose a cyclic pathway for oxidation of pyruvate, discuss the type of experimental evidence that might have led to realization of the cyclic nature of the glyoxylate pathwayWhich one of the five steps of the pyruvate dehydrogenase complex reaction is most likely to be metabolically irreversible? Explain.
- Briefly describe the role and location of each cofactor/coenzyme involved in the pyruvate dehydrogenase reaction. The five cofactors/coenzymes are TPP, Coenzyme A, Lipoate, FAD, and NAD! Please describe their roles in pyruvate dehydrogenase reaction and where they are each located!Distinguish between catalytic coenzymes and stoichiometric coenzymes in the pyruvate dehydrogenase complexThe first step of gluconeogenesis involves the carboxylation of pyruvate and has a large negative delta G (i.e very exergonic). Explain how it is possible that this step can be exergonic if we know that adding CO2 onto molecules is fundamentally a destabilizing phenomenon?