Figure 1 represents the amino acid sequence of a G-protein coupled receptor (GPCR) as determine by mass spectrometry.*Figure 1 is shown as in the added image.Figure 1: The amino acid sequence of a GPCR as determined by mass spectrometry.(a) Describe the general structural features of this GPCR.(b) A ligand called TIIF binds to arginine-127 (R127 in transmembrane helix 3(TMH3) to cause the activation of this GPCR. There are more than one arginine residues in this GPCR, why was the 127R selected by the ligand? TMH11020304050HDYRDDDAMS OONTSGDCLF DGVNELMKTL QFAVHIPTFV LGLLLNLLAITMH260708090100HGFSTFLKNR WPDYAATSIY MINLAVFDLL LVLSLPFKMV LSQVOSPFPSTMH3110120130140150LCTLVECLYF VSMYGSVFTI CFISMDRFLA IRYPLLVSHL RSPRKIFGICTMH4THH5160170180190200CTIWVLVWTG SIPIYSFHGK VEKYMCFHNM SDDTHSAKVE FPLEVFGFLLTHH6210220230240250PHGIMGFCCS RSIHILLGRR DHTODWVOOK ACIYSIAASL AVFVVSFLPVTHH7260270280290300HLGFFLQFLV RNSFIVECRA KOSISFFLOL SMCFSNVNCC LDVFCYYFVIH8310320330KEPRMNIRAH RPSRVOLVLO DTTISRGHHI HHH

Amino acids are the building units of a protein. Amino acids are linked together by a peptide bonds…

Figure 1 represents the amino acid sequence of a G-protein coupled receptor (GPCR) as determine by mass spectrometry. *Figure 1 is shown as in the added image. Figure 1: The amino acid sequence of a GPCR as determined by mass spectrometry. (a) Describe the general structural features of this GPCR.

Figure 1 represents the amino acid sequence of a G-protein coupled receptor (GPCR) as determine by mass spectrometry. *Figure 1 is shown as in the added image. Figure 1: The amino acid sequence of a GPCR as determined by mass spectrometry. (a) Describe the general structural features of this GPCR.

Health Safety And Nutrition F/Young Child

9th Edition

ISBN:9781305144767

Author:MAROTZ

Publisher:MAROTZ

Chapter1: Children's Well-being

Section: Chapter Questions

Problem A1CR

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Question

Figure 1 represents the amino acid sequence of a G-protein coupled receptor (GPCR) as determine by mass spectrometry.

*Figure 1 is shown as in the added image.

Figure 1: The amino acid sequence of a GPCR as determined by mass spectrometry.
(a) Describe the general structural features of this GPCR.

(b) A ligand called TIIF binds to arginine-127 (R127 in transmembrane helix 3(TMH3) to cause the activation of this GPCR. There are more than one arginine residues in this GPCR, why was the 127R selected by the ligand?

TMH1
10
20
30
40
50
HDYRDDDAMS OONTSGDCLF DGVNELMKTL QFAVHIPTFV LGLLLNLLAI
TMH2
60
70
80
90
100
HGFSTFLKNR WPDYAATSIY MINLAVFDLL LVLSLPFKMV LSQVOSPFPS
TMH3
110
120
130
140
150
LCTLVECLYF VSMYGSVFTI CFISMDRFLA IRYPLLVSHL RSPRKIFGIC
TMH4
THH5
160
170
180
190
200
CTIWVLVWTG SIPIYSFHGK VEKYMCFHNM SDDTHSAKVE FPLEVFGFLL
THH6
210
220
230
240
250
PHGIMGFCCS RSIHILLGRR DHTODWVOOK ACIYSIAASL AVFVVSFLPV
THH7
260
270
280
290
300
HLGFFLQFLV RNSFIVECRA KOSISFFLOL SMCFSNVNCC LDVFCYYFVI
H8
310
320
330
KEPRMNIRAH RPSRVOLVLO DTTISRGHHI HHH

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