For the following peptide: group 3 O. C-NH, CH, Н 4 2 group 1 HO NH, 3 CH2 1 group 4 N. N-H group 2 At which pH will this structure remain stationary in an electric field
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- Write the structure of the following peptides: a) glycyl alanine b) tyrosyl alanyl glycine c) phenylalanyl tyrosyl seryl histidineThe β chains of HbA and HbS were treated with trypsin, and the sequence of the N-terminal tryptic peptides are as given below. Do these peptides separate from each other in an electric field if the pH is 7.0? Explain in detail the reasoning behind your answer and include your calculations for the charge of each peptide in your answer.Which of the following is not true about the properties of a peptide (amide) bond? a.The bond order of the peptide bond is 2 b.The bond is in resonance which makes it (and the 6 atoms around it and included within it) planar c.Delocalization of electrons through the peptide bond contributes to a net dipole for the bond d.Peptide bonds are very, very strongly favored to be in the trans conformation, but proline is an exception because it is more isoenergetic due to its sidechain ring, and can be cis.
- Each ionizable group of an amino acid can exist in one of two states, charged or neutral. The electric charge on the functional group is determined by the relationship between its pKa and the pH of the solution. This relationship is described by the Henderson-Hasselbalch equation. Lysine has three ionizable functional groups. The pKa for these groups are pK1 = 3.1, pK2 = 8.3 and pKR = 10.8. 1. Draw the structures of the predominant ionization state of Lysine at pH 1, 4, 8, and 12. Calculate also the net charge of each of these ionized molecules. Show your work. 2. Calculate the isoelectric point (pI) of Lysine in aqueous solution using the pKa values given above. Explain the rationale of your calculations and show your work.The ionization of p-nitrophenol is shown below (pKa = 7.0): a. Identify the weak acid and conjugate base. b. At pH 7, what are the relative concentrations of ionized and un-ionized p-nitrophenol? c. If enough concentrated hydrochloric acid is added to a solution of p-nitrophenol to lower the pH from 7 to 5, what will happen to the relative concentrations of the ionized and un-ionized forms? d. Ionized p-nitrophenol has a yellow color, while the un-ionized form is colorless. The yellow color can be measured using a spectrophotometer at 400nm. In order to determine the total amount of p-nitrophenol in a solution, would you perform the spectrophotometer reading at an acidic or basic pH? Clearly explain why? e. A solution of p-nitrophenol at pH 7.95 was found to have an A400 of 0.255 . What is the total concentration (in µM) of p-nitrophenol (ionized plus un-ionized) in the solution? The molar extinction coefficient of p-nitrophenol is 18,500 M-1cm-1 and the pKa is 7.The bacterially produced antibiotic gramicidin A forms channels in cell membranes that allow the free diff usion of Na+ and K+ ions, thereby killing the cell. This peptide consists of a sequence of Dand L-amino acids. The sequence of a segment of fi ve amino acids in gramicidin A is R-Gly-L-Ala-D-Leu-L-Ala-D-Val-R′. Complete the Fischer projection below by adding the correct group to each vertical bond.
- At a pH equal to the isoelectric point of alanine, the net charge on alanine is zero. Two structures can be drawn that have a net charge of zero, but the predominant form of alanine at its pI is zwitterionic.(a) Why is alanine predominantly zwitterionic rather than completely uncharged at its pI?(b) What fraction of alanine is in the completely uncharged form at its pI? Justify your assumptions.Compound A is a dipeptide, optically inactive. While compound B is a tripeptide, and optically active. Compound A is formed when compound C and compound D joined together by condensation reaction. Whereas monomers E and F are formed by modifying the compounds C and D. Polymer G is formed by the condensation reaction of monomers E and F. Draw the possible structural formulae A, B,C,D,E,F and polymer G. Label the peptide bond(s) for compounds A and B. Pls name the compounds explain tooOn the diagram above, draw a line across each peptide bond in oligopeptide 3a. Write the single-letter sequence. On the diagram above, circle all the chiral centres in oligopeptide 3a. Complete the Table below to indicate, for oligopeptide 3a, the charges on ionisable groups and the net overall charge at pH 7 and at pH 11. What moieties within oligopeptide 3a are those mainly responsible for the formation of an alpha-helix? Name the process that leads to the unfolding of the alpha helix to yield a random coil. State and justify, for oligopeptide 3a, which amino acid side chains will be involved in: hydrophilic interactions, hydrophobic interactions, disulphide bridges and salt bridges. In each case, briefly justify your choice.
- Draw the peptide ASK(ala-ser-lysine) with proper stereochemistry? what is its pI(isoelectric point)and why the structure is planar? Use the following table to look at pka's of the amino acids and solve this question.Draw the peptide PVLED and determine the following: Isoelectric point, pI The net charge at pH = 3.2 ; pH = 7.6 and pH = 9.3 Complete name of the peptide Name using the 3-letter codeWrite the structure of the following peptides: 1. glycyl alanine 2. tyrosyl alanyl glycine 3. phenylalanyl tyrosyl seryl histidine 4. valyl glycyl cystein 5. seryl methionine