General Structure-Function Association for Different Benzodiazepine Modifications. e.g. CH, Methyl substituent shows the highest increase in activity and bulky substituents such as a phenyl group lead to loss of activity Triazolo analogs tend to show a significantly higher activity e.g. CH, Decisive effect on the activity e.g. OH CH, Substituent leads to an e.g. NO, CI Br decrease in activity Activity increase with e.g. F CI electron withdrawing Halogen substituents in ortho- position lead to significantly enhanced activity substituent * Substitutions at C-6, C-8, and C-9 lower the activity Substituents exhibit strong steric repulsion at the GABA, receptor " Phenyl ring at C-5 position seems to be the best option with only pyridyl remarkable activity derivatives showing

General Structure-Function Association for Different Benzodiazepine Modifications. e.g. CH, Methyl substituent shows the highest increase in activity and bulky substituents such as a phenyl group lead to loss of activity Triazolo analogs tend to show a significantly higher activity e.g. CH, Decisive effect on the activity e.g. OH CH, Substituent leads to an e.g. NO, CI Br decrease in activity Activity increase with e.g. F CI electron withdrawing Halogen substituents in ortho- position lead to significantly enhanced activity substituent * Substitutions at C-6, C-8, and C-9 lower the activity Substituents exhibit strong steric repulsion at the GABA, receptor " Phenyl ring at C-5 position seems to be the best option with only pyridyl remarkable activity derivatives showing

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter21: Benzene And The Concept Of Aromaticity

Section21.4: Phenols

Problem CQ

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