Given the following peptide SEPLMAPVEYPK TABLE 5.1 Properties of the common amino acids found in proteins PK, of lonizing Side Chain Name Abbreviations: pK₂ of PK of 1- and 3-letter a-COOH a-NH3+ codes Group Group Alanine A, Ala 2.3 9.7 Arginine R, Arg 2.2 9.0 Asparagine N, Asn 2.0 8.8 Aspartic acid D, Asp 2.1 9.8 Cysteine C, Cys 1.8 10.8 Glutamine 2.2 9.1 Glutamic acid 2.2 9.7 G, Gly 2.3 9.6 1.8 9.2 Glycine Histidine Isoleucine Leucine Lysine H, His I, Ise 2.4 9.7 L, Leu 2.4 9.6 K, Lys 2.2 9.0 Methionine M, Met 2.3 9.2 Phenylalanine F, Phe 1.8 9.1 P, Pro 2.0 10.6 S, Ser 2.2 9.2 Threonine T, Thr 2.6 10.4 W, Trp 2.4 9.4 Tryptophan Tyrosine Y, Tyr 2.2 9.1 2.3 9.6 Valine V, Val "Approximate values found for side chains on the free amino acids. W.P. Jencks and J. Regenstein (1976) lonization constants of acids and bases in Handbook of Biochemistry and Molecular Biology, 3rd ed., G. Fasman (ed.), CRC Press, Boca Raton, FL. Proline Serine Q, Gln E, Glu - 12.5 - 3.9 8.3 4.2 6.0 - 10.0 - 10.1 Part A Estimate the net charge at pH=7. Assume the pK, values given in the table above. Express your answer as an integer. 195] ΑΣΦ 3 → Submit Request Answer Part B Estimate the net charge at pH= 12. Assume the pKa values given in the table above. Express your answer as an integer. VΠΙ ΑΣΦ Submit ▸ Part C Request Answer Part D Complete previous part(s) Provide Feedback ? ?
Given the following peptide SEPLMAPVEYPK TABLE 5.1 Properties of the common amino acids found in proteins PK, of lonizing Side Chain Name Abbreviations: pK₂ of PK of 1- and 3-letter a-COOH a-NH3+ codes Group Group Alanine A, Ala 2.3 9.7 Arginine R, Arg 2.2 9.0 Asparagine N, Asn 2.0 8.8 Aspartic acid D, Asp 2.1 9.8 Cysteine C, Cys 1.8 10.8 Glutamine 2.2 9.1 Glutamic acid 2.2 9.7 G, Gly 2.3 9.6 1.8 9.2 Glycine Histidine Isoleucine Leucine Lysine H, His I, Ise 2.4 9.7 L, Leu 2.4 9.6 K, Lys 2.2 9.0 Methionine M, Met 2.3 9.2 Phenylalanine F, Phe 1.8 9.1 P, Pro 2.0 10.6 S, Ser 2.2 9.2 Threonine T, Thr 2.6 10.4 W, Trp 2.4 9.4 Tryptophan Tyrosine Y, Tyr 2.2 9.1 2.3 9.6 Valine V, Val "Approximate values found for side chains on the free amino acids. W.P. Jencks and J. Regenstein (1976) lonization constants of acids and bases in Handbook of Biochemistry and Molecular Biology, 3rd ed., G. Fasman (ed.), CRC Press, Boca Raton, FL. Proline Serine Q, Gln E, Glu - 12.5 - 3.9 8.3 4.2 6.0 - 10.0 - 10.1 Part A Estimate the net charge at pH=7. Assume the pK, values given in the table above. Express your answer as an integer. 195] ΑΣΦ 3 → Submit Request Answer Part B Estimate the net charge at pH= 12. Assume the pKa values given in the table above. Express your answer as an integer. VΠΙ ΑΣΦ Submit ▸ Part C Request Answer Part D Complete previous part(s) Provide Feedback ? ?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
52.1.1
Transcribed Image Text:Given the following peptide
SEPLMAPVEYPK
TABLE 5.1 Properties of the common amino acids found in proteins
pKa of
lonizing
Side
Chaina
Name
Abbreviations: pKa of
pKa of
+
1- and 3-lettera - COOH|a - - NH3 +
codes
Groupa
Groupa
Alanine
A, Ala
9.7
Arginine
R, Arg
9.0
Asparagine
N, Asn
8.8
Aspartic acid D, Asp
9.8
C, Cys
10.8
Cysteine
Glutamine
Q, Gln
9.1
E, Glu
9.7
G, Gly
9.6
H, His
9.2
Glutamic acid
Glycine
Histidine
Isoleucine
Leucine
Lysine
Methionine
9.7
I, Ise
L, Leu
9.6
K, Lys
9.0
M, Met
9.2
Phenylalanine F, Phe
9.1
P, Pro
10.6
S, Ser
9.2
Proline
Serine
Threonine
Tryptophan
Tyrosine
T, Thr
10.4
W, Trp
9.4
Y, Tyr
9.1
2.3
9.6
Valine
V, Val
Approximate values found for side chains on the free amino acids.
W.P. Jencks and J. Regenstein (1976) lonization constants of acids
and bases in Handbook of Biochemistry and Molecular Biology, 3rd
ed., G. Fasman (ed.), CRC Press, Boca Raton, FL.
2.3
2.2
2.0
2.1
1.8
2.2
2.2
2.3
1.8
2.4
2.4
2.2
2.3
1.8
2.0
2.2
2.6
2.4
2.2
12.5
3.9
8.3
4.2
6.0
10.0
10.1
Part A
Estimate the net charge at pH = 7. Assume the pKa values given in the table above.
Express your answer as an integer.
VGI ΑΣΦ
Submit
Part B
Submit
Estimate the net charge at pH 12. Assume the pKą values given in the table above.
Express your answer as an integer.
ΠΙ ΑΣΦ
Part C
Request Answer
Provide Feedback
Part D Complete previous part(s)
=
Request Answer
?
?
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