hat happens in the Golgi? Scramblase flips phospholipids from one leaflet to the other o Addition of various head groups to sphingolipids O En bloc addition of complex oligosaccharides to proteins All of these

hat happens in the Golgi? Scramblase flips phospholipids from one leaflet to the other o Addition of various head groups to sphingolipids O En bloc addition of complex oligosaccharides to proteins All of these

Name: hat happens in the Golgi?Scramblase flips phospholipids from one leaf
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Description: hat happens in the Golgi?Scramblase flips phospholipids from one leaflet to the othero Addition of various head groups to sphingolipidsO En bloc addition of complex oligosaccharides to proteinsAll of these

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter30: Protein Synthesis

Section: Chapter Questions

Problem 10P: The Consequences of Ribosome Complexity Eukaryotic ribosomes are larger and more complex than...

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RIPs as Cancer Drugs Researchers are taking a page from the structure-function relationship of RIPs in their quest for cancer treatments. The most toxic RIPs, remember, have one domain that interferes with ribosomes, and another that carries them into cells. Melissa Cheung and her colleagues incorporated a peptide that binds to skin cancer cells into the enzymatic part of an RIP, the E. coli Shiga-like toxin. The researchers created a new RIP that specifically kills .skin cancer cells, which are notoriously resistant to established therapies. Some of their results are shown in FIGURE 9.17. FIGURE 9.17 Effect of an engineered RIP on cancer cells. The model on the left shows the enzyme portion of E. coli Shiga-like toxin engineered to carry a small sequence of amino acids (in blue) that targets skin cancer cells. (Red indicates the active site.) The graph on the right shows the effect of this engineered RIP on human cancer cells of the skin (); breast () liver (); and prostate (). At what concentration of RIP did all of the different kinds of cells survive?
RIPs as Cancer Drugs Researchers are taking a page from the structure-function relationship of RIPs in their quest for cancer treatments. The most toxic RIPs, remember, have one domain that interferes with ribosomes, and another that carries them into cells. Melissa Cheung and her colleagues incorporated a peptide that binds to skin cancer cells into the enzymatic part of an RIP, the E. coli Shiga-like toxin. The researchers created a new RIP that specifically kills skin cancer cells, which are notoriously resistant to established therapies. Some of their results are shown in FIGURE 9.17. FIGURE 9.17 Effect of an engineered RIP on cancer cells. The model on the left shows the enzyme portion of E. coli Shiga-like toxin engineered to carry a small sequence of amino acids (in blue) that targets skin cancer cells. (Red indicates the active site.) The graph on the right shows the effect of this engineered RIP on human cancer cells of the skin (); breast () liver (); and prostate (). Which cells survived best at 1 microgram per liter RIP?
RIPs as Cancer Drugs Researchers are taking a page from the structure-function relationship of RIPs in their quest for cancer treatments. The most toxic RIPs, remember, have one domain that interferes with ribosomes, and another that carries them into cells. Melissa Cheung and her colleagues incorporated a peptide that binds to skin cancer cells into the enzymatic part of an RIP, the E. coli Shiga-like toxin. The researchers created a new RIP that specifically kills skin cancer cells, which are notoriously resistant to established therapies. Some of their results are shown in FIGURE 9.17. FIGURE 9.17 Effect of an engineered RIP on cancer cells. The model on the left shows the enzyme portion of E. coli Shiga-like toxin engineered to carry a small sequence of amino acids (in blue) that targets skin cancer cells. (Red indicates the active site.) The graph on the right shows the effect of this engineered RIP on human cancer cells of the skin (); breast () liver (); and prostate (). Why are some of the data points linked by curved lines?
RIPs as Cancer Drugs Researchers are taking a page from the structure-function relationship of RIPs in their quest for cancer treatments. The most toxic RIPs, remember, have one domain that interferes with ribosomes, and another that carries them into cells. Melissa Cheung and her colleagues incorporated a peptide that binds to skin cancer cells into the enzymatic part of an RIP, the E. coli Shiga-like toxin. The researchers created a new RIP that specifically kills .skin cancer cells, which are notoriously resistant to established therapies. Some of their results are shown in FIGURE 9.17. FIGURE 9.17 Effect of an engineered RIP on cancer cells. The model on the left shows the enzyme portion of E. coli Shiga-like toxin engineered to carry a small sequence of amino acids (in blue) that targets skin cancer cells. (Red indicates the active site.) The graph on the right shows the effect of this engineered RIP on human cancer cells of the skin (); breast () liver (); and prostate (). Which cells had the greatest response to an increase in concentration of the engineered RIP?
The Consequences of Ribosome Complexity Eukaryotic ribosomes are larger and more complex than prokaryotic ribosomal. What advantages and disadvantages might this greater ribosomal complexity bring to a eukaryotic cell?
In the cytosol, most protein folding _________? A. Is not B. Is spontaneous, meaning that most proteins ________ refold following denaturation. A. Cannot B. Can
ribosomes make proteins. Ture or false
Choose a particular type of protein as an example. Show your cell model making that protein. Show the following organelles and describe their role in making, modifying, or transporting the protein: Nucleus Ribosomes Rough ER Vesicles Golgi apparatus Where the protein goes and what it does when it's finished.
ER lumen: C- terminus or N- terminus Golgi apparatus- C- terminius or N- terminus transport vesicles lumen- C-terminus or N-terminus
For smooth ER which macromolecule(s) ( carbohydrate, proteins, lipids, and Nucleic acids) contribute to the structure and function of this organelle. How does it contribute to the organelle function
Match the type of RNA with it's function A. Creates the Ribosome, or work table to pull amino acids together? [ Choose ] rRNA mRNA tRNA B.Carries or "Transfers" amino acids from the cytoplasm to the ribosome [ Choose ] rRNA mRNA tRNA C. Is the copy of DNA from the nucleus, therefore bringing the "message" concerning what protein to build [ Choose ] rRNA mRNA tRNA
. Cyanide binds to at least one molecule involved in producingATP. If a cell is exposed to cyanide, most of the cyanide will befound within the(A) mitochondria.(B) ribosomes.PRACTICE TEST goo.gl/CUYGKD(C) peroxisomes.(D) lysosomes.