How might our knowledge about telomeres and telomerase be applied to anti-aging strategies? Are such strategies or therapies developed?

Q: What is spontaneous mutation and how does it occur during Stress-Induced Mutagenesis.

A: The mutation is the sudden genetical changes that occurs in the DNA sequence and ultimately can or…

Q: Discuss the importance of proteomics in the developmentof treatments for genetic disorders.

A: Omics is the branch of science that deals with the technological approach. This helps to explore the…

Q: What is the function of telomerase?

A: The deoxyribonucleic acid (DNA) is the hereditary material that transmits the genetic information…

Q: What is the long term and short term effects of mutation on coding and non-coding DNA, the amount of…

A: A mutation is a change in the nucleotide sequence of an organism's genome, virus, or…

Q: What is a fusion protein? How are fusion proteins involved in cloning and expression?

A: Cloning is considered as the process, during which either naturally or artificially the production…

Q: How might our knowledge about telomeres and telemerase be applied to anti-aging strategies? Are such…

A: Telomeres are the specific DNA–protein structures present at both ends of every chromosome. These…

Q: describe the telomere shortening problem and how it is solved by telomerase?

A: Telomeres are repetitive sequences of DNA (none coding) strand that protect the chromosome from…

Q: Explain how telomerase expression contributes to theimmortality of cancer cells

A: The tumor cells are said to be immortal due to the expression if telomerase enzyme. The telomerase…

Q: might our knowledge about telomeres and telomerase be applied to anti-aging strategies?  Are such…

A: Enzymes called telomerase was discovered in 1987 by Greider and Blackburn. This enzyme synthesize…

Q: What is a telomere problem and how is telomerase useful in this context?

A: Telomere is the sequence of repetitive nucleotides present at the ends of the chromosomes. Telomeres…

Q: Explain the role of telomerase in stem cells and cancer cells.

A: Introduction  Ageing of cells can be attributed to several factors such as degradation of cellular…

Q: How can these designed nucleases alter the sequence of the genomic DNA?

A: The Common approach to understand gene function in a systematic and unbiased way is including…

Q: What are transposable or mobile DNA elements?

A: According to the question, we have to give the information on transposable or mobile DNA elements.…

Q: What processes considered in this chapter make the proteome more complex than the genome? What…

A: The structure lying in the nucleus in the eukaryotes and in the cytoplasm of prokaryotes carrying…

Q: ld telomerase inhibitors be used to treat cancer?

A: Telomerase, also known as  terminal transferase can be described  as the  ribonucleoprotein that…

Q: What is your synthesis about cloning?

A: The method of Cloning is the production individual with identical genetic materials. This process…

Q: What mutation can be prevented when we exercise?

A: As our body grows, damages, and repairs with its progression so does our genetic material. The DNA…

Q: In 1994, telomerase activity was discovered in human cancer cell lines. Although telomerase is not…

A: The expectation of this survey is to depict what is known and obscure about telomerase in…

Q: How can site-directed mutagenesis be useful to enzymologists?

A: Mutagenesis is the biological process of changing genetic information or DNA of an organism and that…

Q: Outline how mutations arise by depurination, deamination, and tautomeric shifts.

A: The mutation is the sudden and stable change within an organism. It can be due to environmental…

Q: How do we know if a genomic DNA sequence contains aprotein-coding gene?

A: Only about 1% of DNA contains protein-coding genes; the remaining 99 percent is noncoding. Noncoding…

Q: What are knockout mice, how are they produced, and for what are they used?

A: The gene knockout is a mechanism in which one of the genes of an organism is made inoperative. The…

Q: Are transposable elements mutagens?

A: Transposition is connected to replication, recombination and repair. The way that how they are…

Q: Contrast the structures and mobilization mechanisms ofretrotransposons and DNA transposons.

A: The DNA segments that move from one region in the genome into another region are called transposable…

Q: What is the architecture of the DNA polymerases and the replisome?

A: Gene is the unit of heredity. Living organisms contain genetic materials mainly made up of nucleic…

Q: HOw many times can DNA segments be transcribe? Also, can mRNA molecules be reused?

A: Transcription is the process in which mRNA is synthesized from DNA. This process takes place in the…

Q: How do we know that many cancer-causing agents (carcinogens)are also mutagenic?

A: A large number of chemicals and several physical agents, such as UV light and γ-radiation, have been…

Q: The enzyme telomerase is part protein and part RNA. What would be the most likely effect of a large…

A: Introduction  Ageing of cells can be attributed to several factors such as degradation of cellular…

Q: What role do telomeres and telomerase play in cancer progression?

A: Telomere is a region of repetitive nucleotide sequences found at each end on a eukaryotic…

Q: What are stem cells, and what safety mechanism protects them from mutation?

A: Stem cell  Stem cells are pluripotent cell that is produced by bone marrow cells.

Q: How can DNA rearrangements alter gene expression?

A: DNA rearrangement involves a change in the structure of native chromosome. Homologous recombination…

Q: How do germ-line mutations differ from somatic mutations? Germ-line mutations are reversible, while…

A: Mutations are the random changes in the genome of organisms.

Q: Transposable elements alter the genome by making what changes to genes?

A: Transposition may be related to replication, recombination, and repair. Insertion of transposable…

Q: In contrast with the genomic manipulations of animals and plants described in this chapter, human…

A: Genetics is a branch of science that deals in the study of genes, heredity, and genetic variation of…

Q: What is a complex of proteins that folds up the telomeres into a structure that shields…

A: A complex of protein is generally found in many eukaryotic cell, whose primary function is the…

Q: What is the proteome? Why is genomic information alone insufficient to characterize the proteome?

A: Proteomics is the enormous scope investigation of proteins, especially their structures and…

Q: How can these designed nucleases modify the sequence of genomic DNA?

A: A nuclease is a protein that can break the phosphodiester links between nucleotides in nucleic…

Q: How does brain cancer effect DNA Replication? How does brain cancer affect gene mapping? how…

A: A brain tumour is an abnormal cell growth or mass in the brain. Tumor cells in the brain can…

Q: How did telomerase respond to acute stress?

A: By lengthening telomeres and supporting cell growth and longevity, telomerase activity is critical…

Q: Describe the function of telomere end-binding proteins

A: Introduction:The eukaryotic chromosomes are linear or rod-shaped having an end. during replication,…

Q: What is the rationale for developing anti-cancer agents that inhibit telomerase?

A: We all know that ,cancer is an abnormal growth and uncontrolled division of cells that spreads in…

Q: Define telomere and describe the possible connections between telomerase and cell aging and between…

A: Telomerase is an enzyme made of protein and RNA subunits. The function of telomerase is to elongates…

Q: What are site-recombinases? Describe in detail how cre- recombinase can be used to decipher the…

A: Genetic recombination is the transfer of genetic material between organisms, resulting in offspring…

Q: How do these designed nucleases modify the genomic DNA sequence?

A: Designer nucleases functions by targeting a specific DNA sequence with in a genome.

Q: What is a nucleosome-free region? Where are such regions typically found in a genome? How are…

A: Given: Explain about the nucleosome-free region. and explain such regions typically found in a…

Q: Why is it practical to test carcinogens by a mutagenesis assay?

A: Carcinogens are the cancer causing substances. Cancer is an uncontrolled division of cell that has a…

Q: What is the role of TRF2 at the telomere?

A: The telomere is a part of the chromosome, which is situated at the ends of the chromosome. With each…

Q: How has the sequencing of human genome opened new window for treatment of various genetic disorders?

A: The genome includes both the genes (the coding regions) and the noncoding DNA, as well as…

Q: What are induced pluripotent stem cells? How are they derived from adult somatic cells?

A: Pluripotent stem cells are those cells that have the ability to renew themselves by dividing and…

Cancer Therapy