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How we can establish or improve Structure activity relationship(SAR) for the development of H1-Antihistamine drug?
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Solved in 2 steps
- How we can improve (potency, selectivity and decrease in toxicity ) for the development of a H1-Antihistamine drug?Briefly discuss how we can improve pharmacokinetic properties of H1-Antihistamine drugs?how we can improve pharmacokinetic factors( distribution) for the development of H1-Antihistamine drugs?
- How we can improve pharmacodynamics factors( Receptors) for the development of H1-Antihistamine drugs?How we can improve pharmacokinetic development for the development of H1-Antihistamine drugs?What are the potential implications of genetic variations in drug-metabolizing enzymes on individual response and therapeutic outcomes in clinical pharmacology?
- Discuss three types of drug-drug interactions, and explain the links to pharmacodynamics and/or pharmacokinetics, with examples. Give the mechanims.How does physicochemical properties of a drug define its biological mechanism? Please explain at your own words.What is the minimal resolution required for gleaning insights into structures of drug-drug target complex? 100A 2.5A 5A 10A 0.5A