Human cells are highly resistant to transformation. Experiments have shown that 5 regulatory circuits (pathways) have to be altered before human cells can grow as tumor cells in immunocompromised mice. State each of these circuits. Explain how the alteration of the protein of that particular circuit leads to uncontrolled growth.

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter17: Genes And The Immune System
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  1. Human cells are highly resistant to transformation. Experiments have shown that 5 regulatory circuits (pathways) have to be altered before human cells can grow as tumor cells in immunocompromised mice.

State each of these circuits. Explain how the alteration of the protein of that particular circuit leads to uncontrolled growth.      

 

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