Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052



Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 17, Problem 13QP
Textbook Problem

The Adaptive Immune Response Is a Specific Defense Against Infection

In cystic fibrosis gene therapy, scientists propose the use of viral vectors to deliver normal genes to cells in the lungs. What immunological risks are involved in this procedure?

Summary Introduction

To explain: The kind of immunological risks involved in the use ofthe viral vector in cystic fibrosis gene therapy.

Introduction: Gene therapy is the process of replacing defected genes with the desired gene for the treatment of fatal disease. This would help in eliminating the mutated allele from the body. Gene therapy is used in the treatment of various chronic diseases.

Explanation of Solution

When the virus enters the body, it integrates its genetic material with the host’s genetic material. After the transcription and translation of mutated genetic material, a new kind of protein is produced, which do not belong to the body. So, the cells of body detect that protein as foreign and start generating an immune response against it.

In the case of cystic fibrosis therapy, if viral vectors are used to deliver the normal genes the immune cells of the body would recognize the viral vector as a foreign antigen...

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