i) Please predict the products, "A" and "B" of the following Claisen reaction: 1) 1 eq LDA in THF/ 80C co,Et 2) add "A"

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter22: Carbonyl Alpha-substitution Reactions
Section22.SE: Something Extra
Problem 40AP: Base treatment of the following , -unsaturated carbonyl compound yields an anion by removal of H+...
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i)
Please predict the products, "A" and "B" of the following Claisen reaction:
1) 1 eq LDA in THF/ -80C
co,Et
2) add
"A"
OEt
"A"
KOH (aq) or HCI (aq)
heat
"B"
i.e. hydrolysis + H
The following two compounds can be made by Claisen condensation. For each compound
shown draw the component (organic) molecules one would combine to synthesize it. Indicate
which molecule is "initially activated" and which molecule is "added to the enolate".
ii)
Co,H
"A"
"B"
Transcribed Image Text:i) Please predict the products, "A" and "B" of the following Claisen reaction: 1) 1 eq LDA in THF/ -80C co,Et 2) add "A" OEt "A" KOH (aq) or HCI (aq) heat "B" i.e. hydrolysis + H The following two compounds can be made by Claisen condensation. For each compound shown draw the component (organic) molecules one would combine to synthesize it. Indicate which molecule is "initially activated" and which molecule is "added to the enolate". ii) Co,H "A" "B"
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