Q: What type of mutation occurred to produce the abnormal sequence (nonsense or missense)? Explain your…
A: A mutation is a change in a DNA sequence.
Q: A silent mutation and a missense mutation can both result from
A: Transition mutation refers to a point mutation that changes a purine nucleotide to another purine (A…
Q: Identify the type of mutation that occurred to produce the abnormal hemoglobin. Explain why you…
A: Nonsense mutation: This is a condition in which a protein loses its function, resulting in sickness…
Q: O c) Frameshift mutation
A:
Q: What are frameshift mutations with an example
A: Gene mutations are rare and random changes in DNA sequence which result in alteration of polypeptide…
Q: Illustrate and give the normal sequence and the mutated sequence in Leigh's syndrome
A: A disease is a state of unhealthiness of the physical body, mind and social interaction. A disease…
Q: Describe the strange nature of highly repetitive sequences and their function.
A: Introduction : Mammalian genomes have two major types of highly repetitive sequences: interspersed…
Q: Name the disease occur due to defective Nonhomologous End Joining Repair.
A: There are four phases of cell cycle G1, S, G2 and M. Most of the DNA repair occur in G1 phase of…
Q: Identify the mutation. Original DNA: TAC CCG AAT GGC ATT Mutated DNA TAC CCG AAC GGC ATT Use the…
A: To identify: The mutation in the given DNA sequence
Q: An inappropriate base change that has no discernible effect is called a _____________ mutation.
A: The mutation is the process, which helps to change the bases in the DNA segment and exert different…
Q: Lay out the genetics of Nicholas’s case, including where the mutationoccurred, what exact nucleotide…
A: Nicholas was a 2 year-old boy with an extreme case of inflammatory bowel disease and susceptibility…
Q: The variation in the length of tandem repeat of microsatellite DNA has serious translational affects…
A: Microsatellite is a repetitive DNA sequence, in microsatellite some DNA motifs are repeated for so…
Q: Which mutation would most likely cause the greatest impact
A: A mutation occurs when the DNA sequence modifies. Mutations can occur as a result of errors in DNA…
Q: Mutations are heritable alterations in the base sequenceof DNA.? TRue or False
A: The genetic material can be DNA or RNA. In eukaryotes, DNA is the genetic material that is present…
Q: What is an insertion mutation?
A: Any permanent change in a sequence of DNA is termed a mutation. DNA is found in all organisms, and…
Q: Identify the type of mutation shown Original Sequence: GGC TAC ATG GAA Mutated Sequence: GGC TAA TGG…
A: Original Sequence: GGC TAC ATG GAAMutated Sequence: GGC TAA TGG AA
Q: What do the spacers within the CRISPR region correspond to?
A: CRISPR that is clustered regularly interspaced short palindromic repeats. It is found in the…
Q: Obtain the self-dotplot of the following sequence to identify repeat region:…
A: There are various alignment tools available at EMBOSS. It is studied under the domain of…
Q: Define the Okazaki fragments ?
A: The biochemical molecule that is built up with two polynucleotide chains is called DNA…
Q: What different methods were used to help break the genetic code? What did each method reveal and…
A: The genetic code is a triplet code, in which three nucleotides encode each amino acid in a protein.…
Q: Define mutagen.
A: Biomolecules are the compounds that are necessary for different biological processes occurring in a…
Q: explain substitution, insertion, and deletion gene mutations including the potential results of the…
A: Gene mutation is the alternation of the nucleotide sequences in the the DNA. In DNA four types of…
Q: Can someone give me a few inherited disorders that are NOT caused by mutations? and if possible,…
A: Tay Sachs disease- Children's with the tay Sachs disease appears healthy at birth but becomes…
Q: The letters ABCDEFGH represent a normal DNA sequence. Indicate the type of mutation present in each…
A: Whenever there is a normal DNA sequence, but after DNA replication, or due to cellular stress or due…
Q: How to identify all the somatic mutationswithin tumors ?
A: A somatic mutation is a modification within the desoxyribonucleic acid sequence of a somatic cell of…
Q: define the term name as Missense mutations
A: sometimes a wrong nucleotide will be incorporated in the DNA. that can result in a type of mutation…
Q: define gene mutation.
A: Genetic material is nothing but the sequence of nucleic acids which is called as DNA. It contains…
Q: Draw the structure of a typical insertion sequence and identify its parts.
A: There are two types of transposons such as replicative and non-replicative transposons. They are…
Q: Define a mutation and explain how mutant forms are identified.
A: Any alternation in the sequence of nucleotide in the genome of any organism is known as mutation.…
Q: What is the Kozak Sequence?
A: A small amino acid sequence act as an initiation sequence and binds to the mRNA in order to start…
Q: What cause of the genetic disease
A: (Please note that we are not supposed to provide links to the information.) Genetic disorders are…
Q: Please explain the different type of mutations and how do they  occur?
A: Mutation is change taking place in sequence of DNA which can occur either because of mistake during…
Q: we will analyze the Breseq dața. If you see the symbol /+', it means that the mutation is located
A: The physical and functional unit is usually defined and allowed to state that they are been as the…
Q: Please fill in missing DNA/RNA/Amino Acid sequences.
A: DNA: DNA is the basic unit of life.The information here is stored as a code which is made up of…
Q: Would love a list of different types of nucleotide repeat disorders.
A: Nucleotide is a chemical structure which constitute together to form the genetic structure that is…
Q: Give 3 strand slippage and trinucleotide repeat disorder examples
A: DNA is the source of genetic information. It transfers genetic information from parents to…
Q: Calculate volume for 10 ug of DNA.
A: DNA concentration is estimated by measuring the absorbance of a DNA sample in a buffer solution at…
Q: Is a Primer written in the RNA or DNA form
A: Primers are short nucleotide sequence that is complementary to template strand and prime DNA for…
Q: Select any one type of genetic mutation and explain it with the help of related Disorder?
A: A change is a modification in the nucleotide succession of the genome of a life form, infection, or…
Q: Based on the given description, determine which mutation is being referred to A single base…
A: Introduction A mutation is a change in an organism's DNA sequence. Mutations can occur as a result…
Q: Discuss the possible effects of mutations
A: A mutation is the change in the nucleotide sequence of a DNA molecule. Mutation may arise due to any…
Q: What is a deletion mutation?
A: The mutation is a sudden, stable, and heritable change in the organism’s genome. It can occur due to…
Q: Identify the type of mutation shown Original Sequence: GGC TAC ATG GAA Mutated Sequence: GGC TAA TGG…
A: A mutation occurs when the sequence of DNA changes. Mutations may occur as a result of DNA copying…
Q: Explain the term mutation.
A: Genes carry coded genetic information in the form of specific nucleotide sequences. This specific…
Q: Are all human mutations handed on to their children? Please explain.
A: Mutations are changes in the DNA sequence of organism which may or may not affect its phenotype.
Q: Discuss the following mutations with reference to specific genetic disorders: i) Faulty DNA repair;…
A: Asked : Given mutations with respect to specific genetic disorders
Q: Discuss the types of mutations (chromosome and gene mutations).
A: Mutation is any change in the DNA sequence that an ultimately responsible for a point mutation or…
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
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- Original sequence: Consider the following coding 71 nucleotide DNA template sequence (It does not contain a translational start): 5’-GTTTCCCCTATGCTTCATCACGAGGGCACTGACATGTGTAAACGAAATTCCAACCTGAGCGGCGT GTTGAG-3’ Question: 4) In a mutant you discovered that the underlined nucleotide has been deleted. What would the resulting peptide sequence be? What type of mutation is this? 5’-GTTTCCCCTATGCTTCATCACGAGGGCACTGACATGTGTAAACGAAATTCCAACCTGAGCGGCGT GTTGAG-3What type of mutation (missense, silent, and non-sense) was introduced in your sequence when G was substituted with C (Question C) ? Question C: Guanine nucleotide (G shown in red in the DNA sequence below) was substituted by C Write out the sequence of the mutated DNA and the protein made from it. What is the effect of this mutation on the protein? (For example, how will the mutation affect the length and sequence of the protein? What about the function of the protein?)Helicase Unwinding of the E. coli Chromosome Hexameric helicases, such as DnaB, the MCM proteins, and papilloma virus El helicase (illustrated in Figures 16.22 to 16.25), unwind DNA by passing one strand of the DNA duplex through the central pore, using a mechanism based on ATP-dependent binding interactions with the bases of that strand. The genome of E. coli K12 consists of 4,686,137 nucleotides. Assuming that DnaB functions like papilloma virus El helicase, from the information given in Chapter 16 on ATP-coupled DNA unwinding, calculate how many molecules of ATP would be needed to completely unwind the E. coli K 12 chromosome.
- ⦁ Original: ATTTGAGCCMutated: ATTGAGCC. This is an example of what kind of mutation?Mustard gas is an extremely toxic substance that severelydamages lung tissue when inhaled in large amounts. In smallamounts, mustard gas is a mutagen and carcinogen. Considering that mustard gas is a bifunctional alkylating agent, explain how it mutates genes and impacts DNA replication.Below are several DNA sequences that are mutated compared with the wild-type sequence. Eachis a section of a DNA molecule that has separated in preparation for transcription, so you are onlyseeing the template strand. For each mutated DNA sequence, translate and record the resultingamino acid sequence. What type of mutation is each? Wild-type sequence: 3’-T A C T G A C T G A C G A T C-5’ Mutated DNA Template Strand #1: 3’-T A C T G T C T G A C G A T C-5’Amino acid sequence of peptide:Type of mutation: Mutated DNA Template Strand #2: 3’-T A C G G A C T G A C G A T C-5’Amino acid sequence of peptide:Type of mutation: Mutated DNA Template Strand #3: 3’-T A C T G A C T G A C T A T C-5’Amino acid sequence of peptide:Type of mutation: Mutated DNA Template Strand #4: 3’-T A C G A C T G A C T A T C-5’Amino acid sequence of peptide:Type of mutation:
- A molecular researcher, Dr. Sidra Alkatini, is investigating the manifestation of a disorder in some of her lab mice models, which are lacking production of an important protein necessary for the cellular respiration pathway. The afflicted mice are short lived, and have perpetually low blood glucose levels, no matter how much food they are fed. Through sequencing, the following strand of DNA was produced: 5’ TTC CAA TTA CGC CGC TAT ACG CGC ACC ATG TTA TCA TGT TGG TGG TAG 3’ Given your expertise in genetics, she contacts you, her BFF, to help her understand the sequence and its relation to the genetic disorder she is seeing. 1) What motif in this DNA sequence would serve as the RBS? a Essentially none; this is a eukaryotic sequence, so the RBS will be made up of the methylated G-cap! b CAAT! c ACCATGG! d TATA! 2) Do you notice anything unusual about this transcript? a YES! It is very short! b YES! It is…A molecular researcher, Dr. Sidra Alkatini, is investigating the manifestation of a disorder in some of her lab mice models, which are lacking production of an important protein necessary for the cellular respiration pathway. The afflicted mice are short lived, and have perpetually low blood glucose levels, no matter how much food they are fed. Through sequencing, the following strand of DNA was produced: 5’ TTC CAA TTA CGC CGC TAT ACG CGC ACC ATG TTA TCA TGT TGG TGG TAG 3’ Given your expertise in genetics, she contacts you, her BFF, to help her understand the sequence and its relation to the genetic disorder she is seeing. 1) Considering the entire DNA sequence shown above, specify the numbered codon that represents START. a Codon 10. b Codons 12-13. c Codon 9. d Codons 28-30. 2) Indicate three motifs that justify this as being a eukaryotic sequence. a CAAT, TATA, ACCATGG. b GACA, TATAAT, AAUAA.…A molecular researcher, Dr. Sidra Alkatini, is investigating the manifestation of a disorder in some of her lab mice models, which are lacking production of an important protein necessary for the cellular respiration pathway. The afflicted mice are short lived, and have perpetually low blood glucose levels, no matter how much food they are fed. Through sequencing, the following strand of DNA was produced: 5’ TTC CAA TTA CGC CGC TAT ACG CGC ACC ATG TTA TCA TGT TGG TGG TAG 3’ Given your expertise in genetics, she contacts you, her BFF, to help her understand the sequence and its relation to the genetic disorder she is seeing. 1) Now that you have seen the sequence and identified some of the major motifs it contains, what are going to tell Dr. Alkatini about in relation to the genetic disorder she is seeing? a “Listen, Doc, it is clear there is no STOP signal in the last codon place where it normally should be.” b “Listen, Doc, the fact…
- Both DNA polymerase (any DNA polymerase) and ligase catalyze the formation of a bond between nucleotides, but these two enzymes do NOT catalyze the same reaction. Briefly describe the differencesbetween the reaction catalyzed by the polymerase activity of DNA polymerase and the one catalyzed by ligase.Determine the effect of the following mutations on the DNA sequence. In each case, the mutation is described after the sequence (REFER TO THE SUPPLEMENTAL DOCUMENT FOR GUIDANCE TO THIS QUESTION). Guanine nucleotide (G shown in red below) was deleted from the DNA sequence at the position indicated by the arrow). Write out the sequence of the mutated DNA and the protein made from it. What is the effect of this mutation on the protein? (For example, how will the mutation affect the length and sequence of the protein? What about the function of the protein?)In the following sequence, a cytosine was deaminated and is now a uracil (underlined). 5’-GGTAUTAAGC-3’ a. Which repair pathway(s) could restore this uracil to cytosine? b. If the uracil is not removed before a DNA replication fork passes through, what will be the sequences of the two resulting double helices? Provide the sequences of both strands of both helices. Label the old and new strands and underline the mutation(s). c. Could the mismatch repair pathway fix the mutations you’ve indicated in part b? d. If the cell undergoes mitosis, and the replicated DNAs are distributed into the two daughter cells. Will 0, 1, or 2 daughter cells have a mutation in this sequence?