If you had the ability to do gene editing with ONE gene for the betterment of human kind, which one would you choose, and why? Assume you could either change an abnormal allele associated with a disease, such as the cystin gene associated with Cystic Fibrosis to its normal wild type, or add a pre-existing human allele to a genome

If you had the ability to do gene editing with ONE gene for the betterment of human kind, which one would you choose, and why? Assume you could either change an abnormal allele associated with a disease, such as the cystin gene associated with Cystic Fibrosis to its normal wild type, or add a pre-existing human allele to a genome

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter19: Genomes And Proteomes

Section: Chapter Questions

Problem 1TYK

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If you had the ability to do gene editing with ONE gene for the betterment of human kind, which one would you choose, and why? Assume you could either change an abnormal allele associated with a disease, such as the cystin gene associated with Cystic Fibrosis to its normal wild type, or add a pre-existing human allele to a genome.
1. You are studying a new gene “X” that you think controls skin color in Bearded Dragons. In order to determine what gene X does, you need lots of gene X DNA to work with. So, you decide to amplify it through the process known as PCR. You have a forward and a reverse primer that have been designed to gene Xf – a gene in frogs that is similar to the one found in the Bearded Dragon. You are pretty sure that these two primers will work in Bearded Dragons, so you decide to go ahead with the PCR. In frogs, the Forward Xf primer binds gene Xf between nucleotides 32 and 47. The Reverse Xf primer binds between nucleotides 1110 and 1135. a. What size PCR product would these two primers create if they amplified the frog gene Xf?? 3. A fellow lab worker brings you DNA containing what might be a similar gene in Leopard Geckos (XG). She asks you to see if you can amplify it using the same primers you used in frogs and the Bearded Dragon. You run the PCR and then analyze the product by…
The first attempts at gene therapy began in 1990 with the treatment of a young girl with a genetic disorder abbreviated SCID. What does SCID stand for? In the context of SCID, what does ADA stand for?
When the human genome sequence was finally completed, scientists were surprised to discover that the genome contains far fewer genes than expected. How many genes are present in the human genome? Scientists have also found that there are many more different kinds of proteins in human cells than there are different genes in the genome. How can this be explained?
You learned in the chapter that an STR locus is a locus where alleles differ in the number of copies of a short, tandemly repeated DNA sequence. PCR is used to determine the number of alleles present, as shown by the size of the DNA fragment amplified. In the Figure below are the results of PCR analysis for STR alleles at a locus where the repeat unit length is 9 bp, and alleles are known that have 5 to 11 copies of the repeat. Given the STR alleles present in the adults, state whether each of the four juveniles could or could not be an off-spring of those two adults. Explain your answers.
If you were offered the chance to have the genome of your newborn sequenced at a cost of 1,000, would you do so?
1. The first genetic test developed for this disease took advantage of a large family of over 2,000 individuals who lived along Lake Maracaibo in Venezuela. These family members, some with and some without Huntington’s disease, could all trace their ancestry to a single female who settled in the region a number of generations ago.Genomic DNA from family members with and without Huntington’s disease was cut with a set of enzymes that make reproducible cuts at known DNA sequences. These DNA fragments were run on a DNA gel to see which fragments correlated with the presence of Huntington’s disease. a) How might the large number (over 2,000) of family members who have a common ancestor who suffered from Huntington’s disease make it easy to narrow down the gene location of the Huntington’s locus (compared to doing the same experiment with a small family descended from a Huntington’s sufferer)?
1. Examine the “RNA-Seq Coverage” and the “FlyBase Genes” tracks in the Genome Browser from left to right. At approximately which coordinate (base position) does the RNA-Seq data start? Remember that you can use the navigation controls at the top of the page to zoom in to the region of interest.
1. What are the different elements you would need if you wanted to perform CRISPR to edit a gene? 2. What are some of the ways CRISPR technology can benefit humans?
You graduate and land a job in a medical genetics laboratory. A particular family has been identified in which a heritable genetic disease has arisen. Through genetic mapping, you identify a mutation in afflicted individuals that is likely causing this condition. In unafflicted members of this family, a region in the coding sequence of the gene in question has the sequence: 5’-CACATGATGATGATGATGATGCGT-3’ However in afflicted individuals, the gene has the sequence: 5’-CACATGATGATGATGATGATGATGATGCGT-3’. (A) Please propose a detailed mechanism for how this genetic change could have arisen, and illustrate this with a diagram below or on the back of this page. (B) Would mutations affecting this region of the gene be likely to cause a frame-shift in the protein coding sequence? Why or why not? In a related genetic disease, the wild-type or normal allele has the sequence: 5’-CAGCACACACACACACACACAGGTG-3’ (C) Would mutants arising via the mechanism you just described be likely to result…
In a study showing that approximately 10% of protein-coding genes are essential for Cell survival .This translates into which of the following number of essential genes in the human genome .a)100 b) 500 c)1000 d)2000
1) What do you want to learn, if anything, about your own genome? Answer: Honestly i am not a biological son of my parents therefore i am an adopted child, so what comes in my mind of knowing my own genome is to know about Genetic and biochemical disorder of my real parents or ancestors if there is any. Is my answer correct? if not, please make it correct