In a large, randomly mating population, the frequency of the allele (s)for sickle-cell hemoglobin is 0.028. The results of studies have shownthat people with the following genotypes at the beta-chain locus producethe following average numbers of offspring:Genotype Average numberof offspring producedSS 5Ss 6ss 0a. What will the frequency of the sickle-cell allele (s) be in the nextgeneration?b. What will the frequency of the sickle-cell allele be at equilibrium?

In a large, randomly mating population, the frequency of the allele (s)for sickle-cell hemoglobin is 0.028. The results of studies have shownthat people with the following genotypes at the beta-chain locus producethe following average numbers of offspring:Genotype Average numberof offspring producedSS 5Ss 6ss 0a. What will the frequency of the sickle-cell allele (s) be in the nextgeneration?b. What will the frequency of the sickle-cell allele be at equilibrium?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter19: Population Genetics And Human Evolution

Section: Chapter Questions

Problem 9QP: Using the HardyWeinberg Law in Human Genetics Suppose you are monitoring the allelic and genotypic...

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While studying the frequency of sickle-cell disease ("sickle cell anemia") in a population living in sub-Saharan Africa, you obtain the following data from a sample of n= 100 people (note that I chose a simpler system for identifying the alleles rather than using "Hb S" for sickle cell allele), which is the actual name and what you used in lab). What is the frequency of the sickle cell allele (b) in the sample below from a human population? Sample Data BB-60 individuals (No sickle cell disease) Bb-30 individuals (No sickle cell disease) bb-10 individuals (Sickle cell disease) 1. 0.25 2. 0.10 3. 0.35 4. 0.60 5. 0.20
Alkaptonuria is a recessive autosomal genetic disorder associated with darkening of the urine. In the United States, approximately 1 out of every 250,000people has alkaptonuria.a. Assuming Hardy-Weinberg equilibrium, estimatethe frequency of the allele responsible for this trait.b. What proportion of people in the U.S. populationare carriers for this trait? In this population, whatis the ratio of carriers to individuals affected byalkaptonuria?c. If a woman without alkaptonuria had a child withthis trait with one husband then remarried, what isthe chance that a child produced by her secondmarriage would have alkaptonuria?d. Alkaptonuria is a relatively benign condition, sothere is little selective advantage to individualswith any genotype; as a result, your assumptionof Hardy-Weinberg equilibrium in part (a) is reasonable. Could you also use the assumption ofHardy-Weinberg equilibrium to estimate the allelefrequencies and carrier frequencies of more severerecessive autosomal conditions…
Sickle-cell anemia is a recessive disease that afflicts approximately 1 in 12 African Americans, meaning that the frequency of ss homozygotes is 0.09. Assuming the African American population is in Hardy-Weinberg equilibrium, what is the frequency of Ss carriers in this population?
The equation p2+ 2pq + q2= 1 representing theHardy-Weinberg proportions examines genes withonly two alleles in a population.a. Derive a similar equation describing the equilibrium proportions of genotypes for a gene withthree alleles. [Hint: Remember that the HardyWeinberg equation can be written as the binomialexpansion (p + q)2.]b. A single gene with three alleles (IA, IB, and i) isresponsible for the ABO blood groups. Individualswith blood type A can be either IA IAor IA i;those with blood type B can be either IB IBor IB i;people with AB blood are IA IB, and type O individuals are ii. Among Armenians, the frequency of IAis0.360, the frequency of IBis 0.104, and the frequencyof i is 0.536. Calculate the frequencies of individuals in this population with the four possible bloodtypes, assuming Hardy-Weinberg equilibrium.In Problems 15–17, you will see that because matingbetween individuals within populations at Hardy-Weinbergequilibrium is random, it is possible to predict…
Tay–Sachs disease is an autosomal recessive disorder. Among Ashkenazi Jews, the frequency of Tay–Sachs disease is 1 in 3600. Assuming the Ashkenazi population is in Hardy-Weinberg equilibrium, what proportion of the population is expected to be carriers (e.g. heterozygous) for the Tay–Sachs allele?
A certain form of congenital glaucoma is caused by an autosomalrecessive allele. Assume that the mutation rate is 10-5 and that peoplewith this condition produce, on the average, only about 80% of theoffspring produced by people who do not have glaucoma.a. At equilibrium between mutation and selection, what will the frequencyof the gene for congenital glaucoma be?b. What will the frequency of the disease be in a randomly matingpopulation that is at equilibrium?
a population has 700 individuals, 85 of genotype AA, 320of genotype Aa, and 295 of genotype aa. What are thefrequencies of alleles A and a?
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Consider the case of a hypothetical genetic disease called WhySciEleven (WSE), an inherited disease that results to the inability to complete production of an amino acid “moduleactivity” that results in brain damage if untreated. WSE is due to a recessive allele. Given one WSE occurrence per 10,000 births. Which term in the Hardy-Weinberg equation corresponds to the frequency of individuals who have no alleles for the disease WSE? a. p b. 2pq c. p2 d. q2
A given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population? A1A1 = 30 A1A2 = 27 A2A2 = 12 A1A3 = 17 A2A3 = 10 A3A3 = 4 What is the frequency of A1 allele in the population? A. 0.375 B. 0.52 C. 0.305 D. 0.175 E. 0.74
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