In all mammals, insulin growth factor 2 is expressed from only the allele that is inherited by one's father. This outcome is controlled by which of the following? Select all that apply. Nucleosome remodeling DNA methylation genomic imprinting histone acetylation histone methylation
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Q: What
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In all mammals, insulin growth factor 2 is expressed from only the allele that is inherited by one's father. This outcome is controlled by which of the following? Select all that apply.
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- Lactose intolerant individuals do not produce the enzyme lactase. Studies show that the gene that encodes lactase is not transcribed. This gene is most likely associated with nucleosomes that are ______________ which can be caused by histone Uncondensed; acetylation Uncondensed; deacetylation Condensed; acetylation Condensed; deacetylation Uncondensed; methylationDNA methylation is associated with repression of mammalian genes involved in development and differentiation. trueThe human PAH gene encodes the enzyme phenylalanine hydroxylase. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria. The first 9 amino acids of the wild-type human PAH protein are: MSTAVLENP The sequence below shows the first 9 codons of a mutant allele of the human PAH gene: atg tcc act agc ggt cct gga aaa ccc What type of mutation has occurred in the coding sequence? Group of answer choices silent frameshift nonsense missense
- Dynamic mutations are associated with what type of diseases? Genomic imprinting diseases Trinucleotide repeat disease Maternal effect diseases Mitochondrial diseases None of the answers are correctWhich of the following has been directly associated with deficiencies in several genes, especially SNRNP? Leber's hereditary optic neuropathy Myotonic dystrophy Angelman syndrome Prader-Willi syndrome Fragile X syndromeFriedreich ataxia (FRDA) is an autosomal recessive, neurodegenerative disease that causes a lack of voluntary coordination of muscle movements. Affected individuals are homozygous for an unusually large number (expansion) of repeats of a trinucleotide sequence (GAA) in the first intron of the X25 gene. Unaffected individuals typically have between 7 and 38 repeats of the trinucleotide (GAAGAAGAAGAA…). FRDA patients have anywhere from 66 to over 1,700 repeats. To understand how the GAA trinucleotide expansion leads to FRDA, researchers looked at X25 gene expression by extracting RNA from affected and unaffected patients and doing a northern blot analysis (see the figure below): In panel “a,” the researchers used a probe to detect X25 mRNA. In panel “b,” the researchers used a probe on a duplicate of the original blot to detect human GAPDH mRNA (GAPDH is an enzyme involved in glycolysis). The sample labeled “YR” is mRNA from yeast cells that was used as a control. Explain…
- A method for detecting methylated CpGs involvesthe use of a chemical called bisulfite, which convertscytosine to uracil but leaves methylated cytosine untouched. You want to know whether a particularCpG dinucleotide at one location in the genome ismethylated on one or both strands in a tissue sample.The genomic sequence containing this CpG is:5’...TCCATCGCTGCA…3’. You take genomicDNA from the sample tissue, treat it exhaustivelywith bisulfite, and then use flanking primers toPCR-amplify the region including this CpGdinucleotide. You then want to Sanger sequence(see Fig. 9.7) the amplified PCR product. a. After you treat genomic DNA with bisulfite, the twoDNA strands will melt into single strands. Why?b. Your answer to part (a) introduces a potential complication, because if you do not account for this result of bisulfite treatment, the PCR primers willnot amplify the DNA. What special considerationswould be necessary when you design your PCRprimers for this experiment? Could one pair…Duchenne Muscular Dystrophy (DMD) is a disease that manifests in muscle weakness. It exhibits X-linked recessive inheritance pattern. The dystrophin gene is large and can have many different mutations along the DNA. From the following mutations between the gene sequence (DNA template strand) of a healthy male and an affected brother determine if they would affect the production of mRNA or the sequence of the protein. Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons. Mutation 1: Position -6 Healthy individual A Affected brother C Group of answer choices A. Normal mRNA, normal protein B. No mRNA produced (promoter affected) C. Abnormal mRNA, affected protein D. Normal mRNA, affected protein Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons.Which cytosines could be methylated in a typical mammalian genome? Why? 5’-GCCGCGC-3’
- What would happen in the directionality of that activity were reversed? Would proofreading work? If the genomic DNA polymerase were missing its proofreading function (deletion in the domain or subunit), what phenotype would you expect to see in those cells? Please give me the correct answer quickly I will give you upvoteWhat is the role of DNA methylation in eukaryotes? To protect the DNA from restriction endonucleases To prevent nucleosome formation on that region of DNA To distinguish the active X chromosome from the inactive X chromosome in counting To aid in silencing transcription DNA methylation does not occur in eukaryotes, only histones are methylated.In cancerous cells, CpG islands are: where intercalating agents are found demethylated methylated