In nucleophilic acyl substitution, addition to the carbonyl by a nucleophile is followed by loss of the leaving group. O loss of the leaving group is followed by rearrangement of the carbocation. ester hydrolysis is followed by deprotonation. O protonation of the carbonyl is followed immediately by loss of the leaving grou O an SN2 reaction occurs.
In nucleophilic acyl substitution, addition to the carbonyl by a nucleophile is followed by loss of the leaving group. O loss of the leaving group is followed by rearrangement of the carbocation. ester hydrolysis is followed by deprotonation. O protonation of the carbonyl is followed immediately by loss of the leaving grou O an SN2 reaction occurs.
Chapter24: Amines And Heterocycles
Section24.9: Heterocyclic Amines
Problem 22P
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