In the proton transfer step of a Friedel-Crafts alkylation reaction, where does the proton go? O To the aluminum trichloride, restoring a proper valence shell O To the ring to restore aromaticity O To form the acid product O To the sigma complex

Q: Why we need step 3 before step 4? a. Because the nitro group increases the electrophilicity at the…

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Q: Explain the following reactions :(a) Gabriel Phthalimide reaction(b) Coupling reaction

A: Reaction in which a  primary amine is synthesized from an alkyl halide without impurities is called…

Q: Reaction of the cyclic product with a nitron (see below) yields a mixture of heterocyclic…

A: Heterocyclic compounds are the cyclic compounds which contain carbon and an element other than…

Q: Explain how and why rearrangements occur during Friedel-Crafts alkylation reactions forming more…

A: Concept - In Friedel-Crafts alkylation reaction is an electrophilic aromatic substitution reaction…

Q: OCH3 AICI3 + CH3¬Ĉ-O-Ĉ-CH3 CH3O- -CH3 + CH3¬Ĉ-OH CH;Az

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Q: H3CO OCH3 heptanodioato de dimetilo

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Q: Explain the mechin CHs NO2 SbFs HF -> in Toulene No2 over 95.

A: At first SbF5 reacts with HF to give SbF6^- and H^+.  This H^+ is attacked by nucleophilic NO2…

Q: Decriegsing onder of LG ?

A: A leaving group is a nucleophile acting in reverse; it accepts a lone pair as the bond between it…

Q: The following reaction scheme shows that the intermediate carbocation from addition of an…

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Q: What would the product of this reaction be? Clearly indicate the configuration of all…

A: Since the NaOMe is a base  Hence along with heat it will extract a H from the reactant and hence…

Q: Rank these substrates from most to least reactive in an SN1 reaction and give a brief rationale for…

A: In SN1 reaction intermediate is carbocation Stability of carbocation increases the rate of SN1…

Q: What is the major reason why aromatic and vinyl halides do not undergo nucleophilic substitution by…

A: General SN1 mechanism involves two steps step-1 :  Loss of leaving group to get stable carbocation…

Q: the dehydrohalogenation (E2) reaction, d

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Q: (i) Provide the product for the reaction below. (ii) How would you know if the reaction was an SN1…

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Q: 3. Rank the following in order by the rate in which they could participate in an SN1 reaction (“1"…

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Q: Why is a methoxy group more activating than a methyl group? O It creates a fourth resonance…

A: OMe Has +M effect and CH3 has +I effect E1 mechanism  Crbocation intermediate formed in First step…

Q: Draw all the major and minor resonance structures of the sigma complex intermediate in the EAS…

A: The reaction between acetophenone & HNO3/H2SO4 is an example of nitration reaction (which falls…

Q: How Reactivity Depends on the Basicity of the Leaving Group?

A: Applying basic concepts of relationship between  leaving ability and base character of leaving…

Q: For the reaction of ethylchloride with sodium hydroxide via the SN2 mechanism, we get inversion of…

A: Given, Options are :

Q: 19) As was discussed in class, a toluenesul fonate is an excellent leaving group. In reaction A…

A: Reaction A : A sn2 reaction. OTs is leaving group and OAc is nucleophile. Inversion at chiral…

Q: CN HO, но, KAL KEL KOL KUL 19. the most reactive toward EAS 20. an ortho-disubstituted benzene…

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Q: One of the two diastereomers shown below reacts with potassium tertbutoxide significantly faster…

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Q: Identify the organohalide which would give the two Friedel-Crafts alkylation products shown below.

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Q: OCH3 AICI3 -ë-o-ċ-CH3 CH3 + CH3-C-OH CH3- CH3O- CH;Az

A: The reaction mechanism for the major product of the Friedel-Crafts acylation reaction has to be…

Q: Step 2 of the iodination of benzene shows water acting as a base and removing a proton from the…

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Q: Select the member of each pair that shows the greater rate of SN2 reaction with KN3 in acetone.

A: SN2 reaction rate depends upon the steric effect. Higher the steric hindrance, lower would be the…

Q: under theromodynamic base conditions, the below system gives alkylation at the less substituted…

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Q: (a) Why cyclohexene and cyclohexa-1,3-diene are expected to undergo addition reaction but benzene…

A: Organic compound undergoes electrophilic substitution reaction in presence of electrophile. Electron…

Q: Shown here are the resonance contributors for the cationic intermediate in the electrophilic…

A: Given,

Q: The creation of very large ring systems is often difficult and challenging. The following…

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Q: In the last step in the mechanism of the nitration of benzene, a base will take a proton to restore…

A: The nitration of benzene is carried out in the presence of concentrated nitric acid and concentrated…

Q: Explain the mechanism for Friedel–Crafts Alkylation Involving Carbocation Rearrangement ?

A: The Freidel crafts alkylation is generally depicted as:

Q: imes the kinetic product is the same as the thermodynamic product.) + Br2 ?

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Q: Provide the mechanism for the Wittig reaction below.* H3C H3C- PPh3 CH3

A: In organic chemistry, an aldehyde or ketone when react with wittig reagent ( phosphorus ylide) gives…

Q: SN2 mechanism

A: no, polar solvent dissolve the substrate and nucleophile but do not participate in hydrogen bonding…

Q: Draw the major organic product generated in the reaction below. Pay particular attention to regio-…

A: Given that : We have to draw the major product for the following reaction :

Q: Which of the following is an incorrect statement about the chlorination of benzene by Cl, and AICI3?…

A: Here, we have to find the incorrect statement about the chlorination of benzene by Cl2 and AlCl3.

Q: 2. For the following amines A and B, show all of the Hoffman elimination produc If one product is…

A: The Hofmann Elimination is an elimination reaction of alkylammonium salts that forms C-C double…

Q: What is Hoffman's  elimination and when will it occur

A: The elimination reaction of an amine which forms a least stable or less substituted alkene is known…

Q: 13. Which acid in each pair below is the stronger acid? Please explain your answer with the…

A: Among 2-dibromoacetic acid and bromoacetic acid, 2-dibromoacetic acid is more acidic. Because,…

Q: Provide a plausible arrow pushing mechanism for the reaction below. You may abbreviate the…

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Q: 1. what is the Nature of the leaving group (LG)? 2. what is the relative size of activation energy…

A: A leaving group always removed from the species  with the bonded electrons.

Q: uestion 2 Coupling a terminal alkyne with an alkenyl halide, using a mixture of a Pd and Cu(l)…

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Q: Which sequence of reactions is expectéd to produce the produ as Ln and major, organic product? HO H…

A: This is the concept of CIS /Trans Alkene

Q: Provide a plausible arrow pushing mechanism for the reaction below. You may abbreviate the…

A: The plausible arrow pushing reaction mechanism is provided below in attach image .