Ingestion of complement-tagged pathogens by phagocytes is mediated by receptors for the bound complement proteins.  Even when the complement cascade fails to proceed beyond generating the C3 convertase, complement activation is effective at inducing pathogen uptake and destruction. This process of immune protection is mediated by: Activation of complement inhibitory receptors on phagocytes that promote pathogen uptake Activation of soluble proteases in the serum that disrupt pathogen membranes Engagement of complement receptors on phagocytes by C3b and its cleavage products which promotes phagocytosis Engagement of complement receptors on B cells that promotes antibody production Stimulation of antimicrobial peptide secretion by phagocytes

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter12: Body Defenses
Section: Chapter Questions
Problem 15RE
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Ingestion of complement-tagged pathogens by phagocytes is mediated by receptors for the bound complement proteins.  Even when the complement cascade fails to proceed beyond generating the C3 convertase, complement activation is effective at inducing pathogen uptake and destruction. This process of immune protection is mediated by:

  1. Activation of complement inhibitory receptors on phagocytes that promote pathogen uptake
  2. Activation of soluble proteases in the serum that disrupt pathogen membranes
  3. Engagement of complement receptors on phagocytes by C3b and its cleavage products which promotes phagocytosis
  4. Engagement of complement receptors on B cells that promotes antibody production
  5. Stimulation of antimicrobial peptide secretion by phagocytes
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