15. Dodgerase is an enzyme that is exquisitely inhibited by a class of cheaters(Astrozolamide and Redsoxin). Dodgerase plays an important role in the civic pride ofone of the greatest and most diverse cities in the world. The experimental curve ofinitial reaction velocity (as percentage of Vmax) versus [S] for the Dodgerase reaction isshown (upper curve). When the experiment was run in 2017, in the presence ofinhibitor, the lower curve was obtained. From an inspection of the curves and yourknowledge of the kinetic properties of competitive, uncompetitive and mixed inhibitors,determine the nature of the inhibition by Astrozolamide and explain your reasoning!100No inhibitor50Astrozolamide0.20.40.60.8[S] (mm)pee"A JO %) A

Enzymes are globular protein molecules that catalyze a given reaction in a time-dependent manner.…

knowledge of the kinetic properties of competitive, uncompetitive and mixed inhibitors, determine the nature of the inhibition by Astrozolamide and explain your reasoning! 100 No inhibitor Astrozolamide 0.2 0.4 0.6 0.8 (S) (mm) pre"A JO %) A

knowledge of the kinetic properties of competitive, uncompetitive and mixed inhibitors, determine the nature of the inhibition by Astrozolamide and explain your reasoning! 100 No inhibitor Astrozolamide 0.2 0.4 0.6 0.8 (S) (mm) pre"A JO %) A

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter6: Energy, Enzymes, And Biological Reactions

Section: Chapter Questions

Problem 9TYK: Which of the following statements about inhibition is true? a. Allosteric inhibitors and allosteric...

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Question

15. Dodgerase is an enzyme that is exquisitely inhibited by a class of cheaters
(Astrozolamide and Redsoxin). Dodgerase plays an important role in the civic pride of
one of the greatest and most diverse cities in the world. The experimental curve of
initial reaction velocity (as percentage of Vmax) versus [S] for the Dodgerase reaction is
shown (upper curve). When the experiment was run in 2017, in the presence of
inhibitor, the lower curve was obtained. From an inspection of the curves and your
knowledge of the kinetic properties of competitive, uncompetitive and mixed inhibitors,
determine the nature of the inhibition by Astrozolamide and explain your reasoning!
100
No inhibitor
50
Astrozolamide
0.2
0.4
0.6
0.8
[S] (mm)
pee"A JO %) A

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Which of the following statements about inhibition is true? a. Allosteric inhibitors and allosteric activators are competitive for a given enzyme. b. If an inhibitor binds the active site, it is considered noncompetitive. c. If an inhibitor binds to a site other than the active site, this competitive inhibition. d. A noncompetitive inhibitor is believed to change the shape of the enzyme, making its active site inoperable. e. Competitive inhibition is usually not reversible.
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