lon X has an equilibrium potential of Ex = -50 mV. At the resting membrane potential (-70mV), which direction is the electrical force acting on X? O Outward O Inward O There is no electrical force on X At the resting membrane potential (-70mV), what is the net direction of movement of X* across the membrane? Assume ion channels for X are open. O Direction cannot be determined from this information O Inward O Outward
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- Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)The major role of the Na+/K+ pump is to: a. cause a rapid firing of the action potential so the inside of themembrane becomes momentarily positive. b. decrease the resting membrane potential to zero. c. hyperpolarize the membrane above resting value. d. cause an action potential to enter a refractory period. e. maintain the resting membrane potential at a constantnegative value.Which of the following voltages would most likely be measured during the relative refractory period? +30 mV 0 mV -45 mV -80 mv
- One of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?The reason that resting membrane potential (RMP) is closer to the equilibrium potential of K+ (EK) rather than that of Na+ (ENa) is that… Group of answer choices -The driving force for Na+ ions at rest is high. -The membrane is much more permeable to Na+ ions than K+ ions at rest. -Only K+ ions have a concentration gradient, Na+ ions have approximately equal intracellular and extracellular concentrations -The membrane is much more permeable to K+ ions than Na+ ions at rest.The resting membrane potential…A) Can be approximated using the Nernst equation.B) Is established by a difference in charges across the cell membrane, with the inside more positive than the outside.C) Has no influence on the driving force for flow of a particular ion across the cell membrane.D) Is more dependent on the passive flow of potassium vs. sodium ions through leak channels across the cell membrane.E) Stays the same during an action potential.
- Assume a neuron's membrane potential is -60 mV, what's the net consequence on the membrane potential of a 5 picoamp (pA) sodium current that occurs simultaneously with a 5 pA chloride current? a. There's a 5 pA hyperpolarizing current b. There's a 10 pA depolarizing current c. There's a 10 pA hyperpolarizing current d. There's a 5 pA depolarizing current e. There's no change in the membrane potentialCompound X has been shown to block voltage-gated K+ channels with an IC50 of 0.1 mM. Which of the following is the most likely to occur in neurones following application of 0.03 mM X? Action potentials would be prolonged and the resting potential would be depolarised. Action potentials would be prolonged but the resting potential would remain the same. Neither resting potential nor action potentials would be affected because the concentration of X is less than the IC50 value. The resting membrane potential would depolarise but there would be no effect on action potentials.Separately, draw a table using arrows to depict the appropriate magnitude and direction of the forces and ion fluxes at different membrane potentials for a ligand-gated channel that is equally permeable to both ion X+ and ion Y+. The equilibrium potential for ion X+ is -60 mV, and the equilibrium potential for ion Y+ is -20 mV. Which item best represents the forces and fluxes for a membrane potential of -20 mV?
- The resting membrane potential…A) Can be approximated using the Goldman-Hodgkin-Katz equation.B) Represents a difference in charges across the cell membrane, resulting mostly from the passive flow of Na+ions.C) Has no influence on the driving force that acts on different ions across the cell membrane.D) Is equally dependent on the concentration gradients of potassium and sodium across the cell membrane.E) Becomes hyperpolarized during an excitatory graded potential.1.A poison causes a drastic rise inE value with stimulation of the membrane.Thereafter membrane is slow to return towards resting membrane potential and levels off several millivolts above the threshold potential. This poison has likely affect which feature of the membrane? a) voltage gated na+ channels. b) voltage gated K+ channels. c) Na+/K+ Atp pump 2. All cell membrane demonstrate action potential if stimulated enough? True/False. 3. how many peaks are there in a compound action potential? a)2. b)4 c)6 d)8 4. Increasing the ionic concentration in the salt bridge results in E value increase to a point after which it plateeus. This is evidence brownian movement at work in the ionic solution that is keeping from energy flowing through the bridge with the fidelity that is seen in the metal bridge? True/ False 5. All cell membrane demonstrate action potential if stimulated enough? True or False.Describe the contribution of each of the following to the establishment and maintenance of membrane potential: Part A Na+K+ Pump Passive movement of K+ across the membrane Passive movement of Na+ across the membrane Part B Resting membrane potential is approximately -70mV. Explain what resting membrane potential is and what -70mV refers to.