Mango-globin” is a hemoglobin variant in which the iron atoms in each subunit have been substituted with manganese atoms. Mango-globin binds to oxygen at very high partial pressures, but does not exhibit any cooperativity. Propose an explanation for this observation. (Hint: the ionic radius of Fe2+ is 77 pm; the ionic radius of Mn2+ is 82 pm.)
“Mango-globin” is a hemoglobin variant in which the iron atoms in each subunit have been
substituted with manganese atoms. Mango-globin binds to oxygen at very high partial pressures,
but does not exhibit any cooperativity. Propose an explanation for this observation. (Hint: the
ionic radius of Fe2+ is 77 pm; the ionic radius of Mn2+ is 82 pm.)
The free energy change for a
∆?!= ∆? ̊!+ RT ln [products] / [reactants]
When a reaction is at equilibrium, ∆G’ = 0, and this expression simplifies to:
∆? ̊!= −RT ln [products] / [reactants]
At equilibrium, the ratio of product to reactant concentrations is nothing more than the equilibrium
constant, Keq, for the reaction. Under these conditions:
∆G ̊’ = -RT ln Keq
Mango-globin” is a hemoglobin variant in which the iron atoms in each subunit have been
substituted with manganese atoms. Mango-globin binds to oxygen at very high partial pressures,
but does not exhibit any cooperativity. Propose an explanation for this observation. (Hint: the
ionic radius of Fe2+ is 77 pm; the ionic radius of Mn2+ is 82 pm.)
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