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Mercury ions, Hg(1) and Hg(II), are poisonous due to their ability to displace other metal ions in enzymes and disrupt the biological function. a) Are these ions hard or soft? b) Common ligands for metal ions in biological environments are amino acids (building blocks of proteins). Of the amino acids depicted below (focus on the highlighted atoms), which would be the best ligand for Hg(1) and Hg(II), and why? H H O H3Nt ÇH2 H3N--c CH2 H H3Nt H3N--c CH2 H3N*. H3Nt CH2 CH CH2 CH2 OH но CH3 SH он H2Ñ H2N Serine (S) Ser Threonine (T) Cysteine (C) Cys Tyrosine (Y) Asparagine (N) Glutamine (Q) Asn Thr Тyr Gln c) Other metal ions that are toxic at certain concentrations include cadmium, chromium, iron, arsenic, and lead. For each of these metals, predict whether they would have similar chemistry to mercury using HSAB concepts.- (Note that toxicity is dose-dependent; even water can be poisonous at too high a concentration in the body)

Mercury ions, Hg(1) and Hg(II), are poisonous due to their ability to displace other metal ions in enzymes and disrupt the biological function. a) Are these ions hard or soft? b) Common ligands for metal ions in biological environments are amino acids (building blocks of proteins). Of the amino acids depicted below (focus on the highlighted atoms), which would be the best ligand for Hg(1) and Hg(II), and why? H H O H3Nt ÇH2 H3N--c CH2 H H3Nt H3N--c CH2 H3N*. H3Nt CH2 CH CH2 CH2 OH но CH3 SH он H2Ñ H2N Serine (S) Ser Threonine (T) Cysteine (C) Cys Tyrosine (Y) Asparagine (N) Glutamine (Q) Asn Thr Тyr Gln c) Other metal ions that are toxic at certain concentrations include cadmium, chromium, iron, arsenic, and lead. For each of these metals, predict whether they would have similar chemistry to mercury using HSAB concepts.- (Note that toxicity is dose-dependent; even water can be poisonous at too high a concentration in the body)

Chemistry & Chemical Reactivity
Chemistry & Chemical Reactivity
10th Edition
ISBN:9781337399074
Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Chapter22: The Chemistry Of The Transistion Elements
Section: Chapter Questions
Problem 78GQ: The glycinate ion, H2NCH2CO2, formed by deprotonation of the amino acid glycine, can function as a...
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Mercury ions, Hg(1) and Hg(II), are poisonous due to their ability to displace other metal ions in enzymes and disrupt the biological function. a) Are these ions hard or soft? b) Common ligands for metal ions in biological environments are amino acids (building blocks of proteins). Of the amino acids depicted below (focus on the highlighted atoms), which would be the best ligand for Hg(1) and Hg(II), and why? H H H O H3Nt CH2 H H H3N* -c CH2 H3Nt C-c CH2 H3Nt CH2 H3N+-C-c CH CH2 HO CH3 OH SH он H2N H2N Serine (S) Ser Threonine (T) Thr Cysteine Сys Tyrosine (Y) Asparagine (N) Glutamine (Q) Asn Тyr Gln c) Other metal ions that are toxic at certain concentrations include cadmium, chromium, iron, arsenic, and lead. For each of these metals, predict whether they would have similar chemistry to mercury using HSAB concepts. (Note that toxicity is dose-dependent; even water can be poisonous at too high a concentration in the body)
Transcribed Image Text:Mercury ions, Hg(1) and Hg(II), are poisonous due to their ability to displace other metal ions in enzymes and disrupt the biological function. a) Are these ions hard or soft? b) Common ligands for metal ions in biological environments are amino acids (building blocks of proteins). Of the amino acids depicted below (focus on the highlighted atoms), which would be the best ligand for Hg(1) and Hg(II), and why? H H H O H3Nt CH2 H H H3N* -c CH2 H3Nt C-c CH2 H3Nt CH2 H3N+-C-c CH CH2 HO CH3 OH SH он H2N H2N Serine (S) Ser Threonine (T) Thr Cysteine Сys Tyrosine (Y) Asparagine (N) Glutamine (Q) Asn Тyr Gln c) Other metal ions that are toxic at certain concentrations include cadmium, chromium, iron, arsenic, and lead. For each of these metals, predict whether they would have similar chemistry to mercury using HSAB concepts. (Note that toxicity is dose-dependent; even water can be poisonous at too high a concentration in the body)
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