Modify the diagram above to illustrate specific protein(s) that would participate in regulating this pathway if DNA damage was detected in these cells. What effect would this have on the progression of the cell cycle? If there is more than one possible outcome be sure to outline each one. d) You determine that growth factor binding to this receptor ultimately results in the activation of the G1cyclin-Cdk4 complex, which phosphorylates and thereby inactivates RB. This leads to the release ofE2F and ultimately allows the cell to transition from G1 to S phase. (This process is depicted below)G, cyclinG1Cdk4RBE2FP

RB retinoblastoma gene is a tumor suppressor gene.

Modify the diagram above to illustrate specific protein(s) that would participate in regulating this pathway if DNA damage was detected in these cells. What effect would this have on the progression of the cell cycle? If there is more than one possible outcome be sure to outline each one.

Modify the diagram above to illustrate specific protein(s) that would participate in regulating this pathway if DNA damage was detected in these cells. What effect would this have on the progression of the cell cycle? If there is more than one possible outcome be sure to outline each one.

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter37: The Endocrine System

Section: Chapter Questions

Problem 1VCQ: Figure 37.5 Heat shock proteins (HSP) are so named because they help refold misfolded proteins. In...

See similar textbooks

Related questions

Q: Create a table of the phases of mitosis and what is happening in each phase

A: Mitosis is the stage of the cell cycle in which newly formed DNA is separated and two new cells with…

Q: a) Identify the major checkpoints in a cell and its function. b)Explain the role of the growth…

A: The cell cycle is the ordered sequence of events that occur in a cell prior to cell division. It…

Q: Describe what happens to the G1 cell cycle check point of a skin cell that is stimulated to divide…

A: Transformation of cells from one phase of the cell cycle to another is controlled by some external…

Q: Name the phases of the cell cycle. b) During which phases are the chromosomes and then the…

A: Cell cycle Cell cycle is a division of cell takes place in various steps and divide one cell into…

Q: The cellular division that changes the chromosomes ploidy from 2n to 1n occurs during what phase

A: Ploidy is the number of “complete sets of chromosomes” in a cell. According to the number of sets of…

Q: Cell Cycle. Use the topic and relate the topic for initiation progression and invasion-metastasis of…

A: Cancer is unchecked cell growth. Mutations in genes can cause cancer by enhancing cell division…

Q: BPA is a chemical compound that has historically been used in the manufacture of plastic products.…

A: Bisphenol-A (BPA) is a chemical that is very harmful to the living cells. BPA is known to exert…

Q: How important are the control points in the cell cycle for the growth and development of an…

A: The daughter cell produced be exact duplicate of the parent cell. Mistakes in the distribution of…

Q: How are school Clearance Form similar to the Cell Cycle Checkpoints? Vice Versa. Encode your answer…

A: Cell cycle is the process by which a parent cell into two or more cells. In somatic cells, mitosis…

Q: According to the picture above, the cell shown is going through [Select ] and is in the [Select ]…

A: Ans- In the picture above, the cell is going through the meiotic cell division. Meiosis is the…

Q: Progression through the cell cycle is regulated by fluctuations in the concentration of G proteins…

A: A series of events which takes place in a cell due to which it divides and forms two daughter cells…

Q: Put a checkmark next to any of the following scenarios that would make it MORE likely that a cell…

A: Need to find all the options that produce uncontrollable cell division and to increase chance of…

Q: Explain the importance of the checkpoints in the cell cycle and the consequences of bypassing those…

A: The cell cycle is a "series of events" that occurs in various cells in "preparation" for cellular…

Q: Use the data in the accompanying table to answer the question. Minutes Spent in Cell Cycle Phases…

A: Introduction :- Cell cycle is series of events and phases that a cell passes through , so as to…

Q: Highlight each function of the checkpoints and the characteristics of the cell during the different…

A: Introduction The cell cycle is the process by which a cell replicates all of its material and divide…

Q: Explain how or why a slide of stained cells can be used to estimate how much time a living cell…

A: Cells in the body reproduce at different rates. Skin cells reproduce more often (about once a day);…

Q: Briefly outline the events that control the progression of cells through the G1/S checkpoint in the…

A: A checkpoint is described as a level at which cell examines diverse inner and outside elements and…

Q: Explain how the cell cycle is regulated in eukaryotic cells.

A: Cell cycle is the series of events that occur in a cell as it grows and divides into daughter cells.…

Q: Review the image below. What cell division process is the image demonstrating? Provide evidence to…

A: Given: With reference to the diagram, need to find the process and should explain it. Cell division…

Q: cyclin-cdk complexes

A: The cell cycle is a series of steps where the chromosomes and other cell material double to make two…

Q: Describe how tumor suppressors function to stop the cell cycle until certain events are completed

A: Normal genes that delay cell division, repair DNA errors, or tell cells when to die are known as…

Q: How important are the control points in the cell cycle for the growth and development of an…

A: The DNA (deoxyribonucleic acid) is the hereditary unit of an organism. The genes are composed of DNA…

Q: A mass of cells that do not respond to the normal controls of the cell cycle and extend into…

A: In this question, we have to answer about the cell not respond to normal control of the cell cycle…

Q: List the functions of kinases and cyclins, and describe how they interact to cause cells to move…

A: Cyclins drive the events of the cell cycle by partnering with a family of enzymes called the…

Q: Label the arrows in the slide image below with the appropriate stage of the cell cycle.

A: The cell cycle consists of two major phases: Interphase - It involves the G1 phase, S phase, and G2…

Q: Which statement does not describe cell cycle checkpoints? A. Normal checkpoints assess damage to…

A: To divide, a cell must accomplish many things: expand, reproduce its genetic material (DNA), and…

Q: Cancer can result from a variety of different mutational events. Which of the pllowing is LEAST…

A: Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread…

Q: Give two examples of events that can regulate the cell cycle externally.

A: The cell cycle and its length are variable and range from few hours (embryonic cells) to five days…

Q: State TWO ways in which cell division results in cell C being genetically different from one…

A: The answer is explained below.

Q: Explain the action of cyclin-dependent kinases inregulation of the cell cycle.

A: A cell cycle or cell division cycle involves a series of events that takes place in a cell as it…

Q: Describe the two irrevesible points in the cell cycle

A: The cell cycle has two irreversible points: The replication of genetic material and the separation…

Q: Give the possible results if cells won’t undergo cell division or if the cell cycle happens rapidly…

A: Cell division is the process in which a parent cell divides into two or more daughter cells. There…

Q: Explain regulation of the cell cycle

A: The cell cycle, or cell-division cycle, is the arrangement of occasions that happen in a cell that…

Q: Identify one way in which a specific cancer evades the controls of the cell cycle.

A: One of the major components of control in the cell cycle is Apoptosis. It is the process of…

Q: What is a role of cyclines in regulating the cell cycle? Describe the significance of checkpoints…

A: The "cell cycle", also known as "cell division", is a set of processes that occur in a cell leading…

Q: Base on your understanding, is the cell cycle efficient? If you can insert or modify steps to make…

A: Introduction :- Cell cycle is defined as the orderly sequence of events in which cell duplicates…

Q: draw/describe what happens in each of the cell cycle.

A: Cell cycle: the orderly sequence of events by which a cell duplicates it's DNA, synthesises it's…

Q: describe the stages of the cell cycle use the knowledge of the cell cycle to explain why…

A: Cell cycle is comprised of four steps and prepare the cells for cell division so that cell's content…

Q: Describe the purpose of cell cycle checkpoints.

A: Introduction The cell cycle is controlled by various internal and external factors such as the…

Q: Relate the events in mitosis to the purpose of mitosis Explain the implications of cell cycle…

A: 1.Mitosis is the process in cell division by which the nucleus of the cell divides (in a multiple…

Q: b. In the space below, develop a handout or diagram to explain how these checkpoints work under…

A: Checkpoints These are the points in the cell cycle of the eukaryotes at which the progression of the…

Q: Which statement does not describe cell cycle checkpoints? Normal checkpoints assess damage to DNA. B…

A: Checkpoints are involved in detecting any kind of cellular defect, arresting the progression of the…

Q: Explain and give the importance of cell cycle checkpoints in the different phase of the cell cycle.

A: *cell cycle consists of order events that occur in a cell for cell division. *The cell cycle…

Q: Suppose you have a way of measuring the amount of DNA in a single cell during the cell cycle. You…

A: The life cycle of an eukaryotic cell is generally divided into four main stages - G1, S, G2 and…

Q: Compare and contrast the processes of cell cycle and apoptosis and give an example of a drug or…

A: * cell cycle cell shows a series of events which takes place in a cell as it divides and grows. *A…

Q: Amount of DNA per nucleus over the cell division cycle. At which point in the accompanying…

A: When a cell splits into 2 or more new cells, this process is called cell division. The division of…

Q: Describe how the tumor-suppressor genes Rb, p53 and p21 regulate the cell cycle.

A: Tumor suppressor gene These gene controls the activity of cell division cycles. They decide whether…

Question

d) You determine that growth factor binding to this receptor ultimately results in the activation of the G1
cyclin-Cdk4 complex, which phosphorylates and thereby inactivates RB. This leads to the release of
E2F and ultimately allows the cell to transition from G1 to S phase. (This process is depicted below)
G, cyclin
G1
Cdk4
RB
E2F
P

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Introduction

VIEW

Description

VIEW

Step by step

Solved in 2 steps with 1 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.

Similar questions

which of hthe following would result in a persisting proliferation response to growth factor receptor activation after the ligand is no longer binding to its rceptor kinase? 1. Both a mutation that blocks the GTPas activity of Ras and a mutation that blocks the exchange of GDP with GTP would cause the response to persist. 2. a mutation that blocks the GTPas activity of Ras 3. neither a mutation that blocks the GTPas activity of Ras nor a mutation that blocks the exchange of GDP with GTP would cause the response to persist 4. a mutatiaon that blocks the exchange of GDP with GTP
EGF signals by binding to cell surface EGF receptors. Which of these observations, if true, would BEST explain EGF’s mechanism of action? A. EGF is hydrophilic and can easily diffuse through the cell membrane B. EGF is hydrophobic and can easily diffuse through the cell membrane C. EGF is hydrophilic and cannot diffuse through the cell membrane D. EGF is hydrophobic and cannot diffuse through the cell membrane
Explain the activation of the protein kinase, c-raf, in response to growth factor receptor activation
a.What would happen if IKKbeta did not phosphorylate IkappaB? b.Why is it so hard to make cytokine therapies? c.Why would you use the MyD88 independent pathway versus the MyD88 dependent pathway?
Most mammalian cells have a single immobile cilium called the primary cilium, in which intraflagellar transport (IFT) motor proteins move elements of the Hedgehog (Hh) signaling pathway along microtubules. What parts of the Hh signaling pathway would mutations in the IFT motor proteins Kif3A, Kif7, and dynein disrupt?
Figure 37.5 Heat shock proteins (HSP) are so named because they help refold misfolded proteins. In response to increased temperature (a “heat shock"), heat shock proteins are activated by release from the NR/HSP complex. At the same time, transcription of HSP genes is activated. Why do you think the cell responds to a heat shock by increasing the activity of proteins that help refold misfolded proteins?
A scientist observes a mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding. Which hypothesis regarding the effect of this mutation on EGF signaling is most likely to be correct? EGF signaling cascades would be active for longer in the cell. EGF signaling cascades would be active for a shorter period of time in the cell. EGF signaling cascades would not occur. EGF signaling would be unaffected.
Which of the following modifications of the Epithelial Growth Factor Receptor (EGFR) would be proliferative of epithelial cells? multiple answers A. Mutation of active site residue responsible for tyrosine phosphorylation. B. Deletion of extracellular ectodomain C. Mutation in ectodomain that prevents binding of EGF D. Cell expresses EGF E. Mutation in promoter that increases expression of EGF receptor F. Dimerization of receptor without growth factor G. Mutation in EGFR promoter that decreases expression of receptor
Which phase are initially inhibited by Sic1.Phosphorylation marks Sic1 for ubiquitinylation by theSCF ubiquitin-protein ligase and proteosomal degradation,releasing activated S phase CDKs that trigger onset of theS phase
Role of Myc activation is the follows a. It directly inhibits Rb protein through phosphorylation b. It stimulates assembly of S-phase Cdk-cyclin complex c. It stimulates transcription of delayed response genes d. It increases the expression of early response genes Role of Myc activation is the follows a. It directly inhibits Rb protein through phosphorylation b. It stimulates assembly of S-phase Cdk-cyclin complex c. It stimulates transcription of delayed response genes d. It increases the expression of early response genes
Many malignant tumors are characterized by the activation of one or more growth-factor receptors. What is the catalytic activity associated with transmembrane growth factor receptors such as the EGF receptor?
Put the following steps for the outline of the growth factor signaling pathway in order: Map Kinase Kinase is Phosphorylated Proteins involved in gene transcription are activated Growth factor binds to its receptor in the cytoplasmic membrane Receptor recruits adaptor protein and GEF Autophosphorylation of tyrosine residues on the receptor Structural change of the receptor activates Tyrosine Kinase Map Kinase Kinase Kinase is phosphorylated Ras, a small GTPase, is activated by the exchange of GTP for GDP Map Kinase is Phosphorylated Map Kinase enters the nucleus