Mutation of codon 34 (CAC to GAC) and 85 (CGT to CAT) of the insulin gene causes hyperinsulinemia which may contribute to diabetes. Identify the amino acid replacement from these mutations.
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Mutation of codon 34 (CAC to GAC) and 85 (CGT to CAT) of the insulin gene causes
hyperinsulinemia which may contribute to diabetes. Identify the amino acid
replacement from these mutations.
mia which may contribute to diabetes. Identify the amino acid
replacement from these mutations.
Step by step
Solved in 2 steps
- Which of the following is correct? A. The gene CYP21A2 is the one that codes for the formation of glucose-6 phosphate dehydrogenase B. Simple virilizing form of Congenital adrenal hyperplasia is the most sever form of this disorder C. Salt wasting type of congenita adrenal hyperplasia is the most severe form of this disorder. D. The gene CYP21A1 is the one that codes for the formation of galactokinase in type 2 galactosemia.explain how a mutation could prevent the proper expression of amylase and what the consequences of not expressing amylase would be.true/false: Glutamine synthetase is responsible for the synthesis of glutamine from glutamate.
- Compare the localization of GLUT4 with that of GLUT2 and GLUT3, and explain why these localizations are important in the response of muscle,adipose tissue, brain, and liver to insulinWhat are two ways that the human insulin gene sequence was modified by geneticists so that bacterial cells would transcribe the gene and translate the protein? For each modification, explain why the modification was necessary. Please answer asapWhy are leptin injections less helpful for most overweight people than for mice with the obese gene?
- True or False Activation of a G protein complex causes a conformational change in the α subunit, allowing GDP to be replaced by GTPSuggest the effects of each of the following mutations on the physiologicalrole of chymotrypsinogen:(a) R15S(b) C1S(c) T147SWhen the amino acid sequences of insulin isolated from different organisms were determined, differences were noted. For example, alanine was substituted for threonine, serine for glycine, and valine for isoleucine at corresponding positions in the protein. List the single-base changes that could occur in codons of the genetic code to produce these amino acid changes.
- Describe two reasons why the reaction glutamine synthetase performs is important to the body.Explain using 2-3 sentences the biological significance of the following peptides . Glucagon Insulin Glutathione Ceruloplasmin OxytocinWhich of the following would result in an increase in the amount of F-2,6-BP? (select all that apply) Group of answer choices high blood glucose activation of fructose bisphosphatase 2 increased phosphofructokinase 2 activity increased glucagon secretion increased phosphorylation of the bifunctional enzyme