Answered: Mutational signatures of p53 are shown…

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter16: Gene Expression

Section: Chapter Questions

Problem 37CTQ: Changes in epigenetic modifications alter the accessibility and transcription of DNA. Describe how...

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Mutational signatures of p53 are shown in this image (G.P. Pfeifer et al., Nature, 21(48), 2002) for the three types of cancer with the highest death rates in the United States: lung (~225,000 deaths in 2016), breast (246,000), and colorectal (381,000). These data can be obtained by sequencing the gene that encodes p53. Approximately 85 percent of lung cancers occur in smokers. Based on these data, calculate how many deaths due to lung cancer among nonsmokers were reported in 2016. How much does smoking increase the likelihood of death due to lung cancer?

Mutational Signatures of p53 for
Three Types of Cancer
Nonsmoker's lungs
11% 12%
47%
29%
Smoker's lungs
11%
4%
54%
12%
4%
10% 4%
10%
6% 9%
5%
30%
Breast and colorectal cancer
12%
13%
4%
3%
11%
G:CT:A
G:CA:T
G:C C:G
A:TC:G A:TG:C A:TT:A
Deletion/insertion

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