Name of Enzyme Hexokinase Phosphohexose isomerase Phosphofructokinase Aldolase Isomerase Triosephosphate dehydrogenase Phosphoglycerate Class Number of Enzyme Reaction Catalysed Phosphorylates glucose
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- Describe the impact of phosphorylation of glycogen phosphorylase on its heterotropic regulation. (Don’t need the structural details; focus on the qualitative effects on allostery; be brief and to the point)Glycogen synthase catalyzes glycogen synthesis. Determine whether each intermediate is associated with an “increase” or “decrease” and or “no effect” on the activity of glycogen synthase. Glucose 6-phosphate – cAMP –Von Gierke’s disease is also known as glycogen storage disease type I. Patients with von Gierke’s disease lackglucose 6-phosphatase activity. Two prominent symptoms of this disorder are fasting hypoglycemia and lactic acidosis (elevated lactate levels in the blood), especially during strenuous exercise. Explain why these symptoms occur. What chemical reaction does this enzyme catalyze? Which pathways involve this enzyme? Lacking thisthe enzyme will cause impairment of which pathways?• Pls consider what pathways are affected by Von Gierke’s disease. Include in your explanation involving Cori’s cycle. can you please do not write by your hand? I mean computer if you can. thank you
- 5. Reciprocal regulation of glycogen phosphorylase and glycogen synthase activity.Name of Enzyme Class Number of Enzyme Reaction Catalysed Hexokinase Phosphorylates glucose Complete the table by naming the Enzymes of GlycolysisPhosphorylation of phosphatidylinositol yieldsa) Phosphatidylinositol 4, 5-biphosphateb) Phosphatidylinositol 3, 5-biphosphatec) Phosphatidylinositol 3, 4-biphosphated) Phosphatidylinositol 5, 6-biphosphate
- Von Gierke’s disease is also known as glycogen storage disease type I. Patients with von Gierke’s disease lackglucose 6-phosphatase activity. Two prominent symptoms of this disorder are fasting hypoglycemia and lactic acidosis (elevated lactate levels in the blood), especially during strenuous exercise. Explain why these symptoms occur. What chemical reaction does this enzyme catalyze? Which pathways involve this enzyme? Lacking thisenzyme will cause impairment of which pathways?• Pls consider what pathways are affected by Von Gierke’s disease. Include in your explanation involving the Cori’s cycle.Enzyme Triacylglycerol Lipase Rennin Catalase Hexokinase Enzyme Official Name (write N/A if not applicable) Enzyme Official Number (4 digits) Simple or Conjugated Enzyme (specify cofactor if applicable) Type of Reaction Catalyzed Substrate Optimum pH Optimum Temperature Function/s Disease (give 1 and describe briefly)CH3CH2OH + NAD+ --> CH3CHO + NADH +H+ Explain how this reaction inhibits the production of pyruvate from lactate. Why does this lead to low blood glucose levels? please and thank you