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Which of the following signaling mechanisms is not a switch mechanism?
| a. |
Changes in phosphorylation state |
|
| b. |
Binding of GTP |
|
| c. |
Binding of Ca2+ ion |
|
| d. |
Protease activity |
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- A biochemist is designing a new drug that will mimic the shape and function of a particular intercellular signaling molecule. Therefore she must produce a molecule that will bind to the receptor protein and... A. produce a cellular response by altering the Na+/K+ pump located near the receptor site. B. induce a change in the receptor molecule shape, which will ultimately prevent a cellular response. C. induce a change in the receptor molecule shape, which will ultimately produce a cellular response. D. induce a change in the phospholipid bilayer that causes a polar reversal allowing the molecules to be endocytose (engulfed).For cellular transduction, why is it useful that phosphorylation cascades have a series of protein kinases? a. they amplify the original signal b. they always lead to the same cellular response c. the number of molecules used is small and fixed d. they are cell specificExplain how a kinase cascade works. Why is this advantageous in the context of hormone signaling?
- During cell signaling, binding of a ligand to the outside of a cell leads to: A. A signal being sent inside the cell B. The ligand being transported into the cell C. A and B D. None of the aboveScaffold proteins (a) release kinases and phosphatases into the extracellular fluid (b) bind G proteins to cell membranes (c) increase accuracy but slow signaling cascades (d) organize groups of intracellular signaling moleculesinto signaling complexes (e) are transcription factors found mainly in plant cellsIn this mechanim of receptor regulation, there is uncoupling of the signaling pathway. Even though the ligand is bound to the receptor located in the plasma membrane, downstream signaling is not occuring. This is best described as: Answers A-D A receptor internalization B receptor desensitization C receptor sensitization 5 D receptor downregulation
- You stimulated the cell with a ligand and analyzed the response. Upon ligand treatment, the cell increased the expression of gene α and decreased expression of gene β. When you inhibit cyclic AMP production by treating the cell with an inhibitor of Adenylyl cyclase, the increased expression of gene α was not observed but the decrease gene β expression was still observed. a) What you can expect for gene α regulation by this ligand? What signaling mechanism could be used? b) To determine how gene β is regulated by the ligand via what signaling mechanism, provide your hypothesis and indicate a potential experiment that you can perform to test that.In intercellular signaling pathways, some receptor proteins can also act as a transcription factor (changing gene expression), because these receptors are ________. A) Group of answer choices B) Intracellular receptors C) Membrane bound receptors D) G protein coupled receptors E) Enzyme linked receptors F) Fast ligand-gated ion channelsA mutation in HER2 that causes receptor dimerization in the absence of signaling molecules. Would cause? Why? A. Decreased proliferation B. Increases proliferation
- A drug that inhibits the kinase activity of AKT would MOST likely have which of the following effects? A. Increased GSK-3b activity and increased CyclinD synthesis B. Increased GSK-3b activity and decreased CyclinD synthesis C. Decreased GSK-3b activity and increased CyclinD synthesis D. Decrease GSK-3b activity and decreased CyclinD synthesisWhat are the three main parts of a signaling pathway? Give a detailed specific example, such as how epinephrine signals for rapid digestion of glycogen in liver cells.Which of the following would be considered second messengers of a signaling pathway? Select one: a. A kinase enzyme b. A scaffolding protein holding three kinases c. Adenyl cyclase d. All answers are examples of second messengers e. A sugar like inositol f. Ligand gated channel