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- Outline the three general means by which binding of a water soluble extracellular chemical messenger to its matching surface membrane receptor brings about the desired intracellular response.Describe serine-threonine membrane receptor.alpha 1 adrenergic receptor causes vasoconstriction through activation of Gq protein explain the mechanism of action for this receptorb starting from the ligand binding step untill final effectoe is activated
- Cyclic-AMP stimulates which of the following? a) PKA b) PKC c) Ras d) RTKConsider a KDEL receptor that has been altered to prevent its cargo (proteins with a KDEL sequence) from dissociating (releasing) within the ER lumen. What would the result of this mutation be?Given the existence of leak channels for both K and Na , could the membrane repolarize C688 if the voltage-gated K channels did not exist?
- the most widely distributed plasma-membrane effector protein in cells is adenylyl cyclase true or false?Would this mutation result in protein binding BPG with lower affinity?Which of the following would be expected to inhibit PKC activation by a GPCR ligand? phospholipase C inhibitor cAMP phosphodiesterase inhibitor Ras inhibitor MAP kinase inhibitor
