Part A People with cystic fibrosis (CF) are homozygous recessive for mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. These mutations cause the CFTR protein to become dysfunctional, and it is unable to move chloride to the cell surface. Ultimately mucus can build up in organs, and in the lungs, the mucus clogs the airways and traps bacteria, leading to infections, inflammation, and respiratory failure. In a human population, if 9 in 10,000 newborn babies are born with CF, what are expected frequencies of the dominant (A 1) and recessive (A 2) alleles according to the Hardy-Weinberg model in that population? p = 0.9700, q = 0.0300 O p = 0.9604, q = 0.0392 p = 0.9800, q = 0.0200 p = 0.9997, q = 0.0003 O p= 0.9600, q = 0.0400 Request Answer Submit P Pearson

Part A People with cystic fibrosis (CF) are homozygous recessive for mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. These mutations cause the CFTR protein to become dysfunctional, and it is unable to move chloride to the cell surface. Ultimately mucus can build up in organs, and in the lungs, the mucus clogs the airways and traps bacteria, leading to infections, inflammation, and respiratory failure. In a human population, if 9 in 10,000 newborn babies are born with CF, what are expected frequencies of the dominant (A 1) and recessive (A 2) alleles according to the Hardy-Weinberg model in that population? p = 0.9700, q = 0.0300 O p = 0.9604, q = 0.0392 p = 0.9800, q = 0.0200 p = 0.9997, q = 0.0003 O p= 0.9600, q = 0.0400 Request Answer Submit P Pearson

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1ITD

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A human gene called theCFTR gene (for cystic fibrosis transmembrane regulator) encodes aprotein that functions in the transport of chloride ions across the cellmembrane. Most people have two copies of a functional CFTR geneand do not have cystic fibrosis. However, a mutant version of the CFTRgene is found in some people. If a person has two mutant copies ofthe gene, he or she develops the disease known as cystic fibrosis. Arethe following descriptions of this disease related to genetics at themolecular, cellular, organism, or population level?A. People with cystic fibrosis have lung problems due to a buildupof thick mucus in their lungs.B. The mutant CFTR gene encodes a defective chloride transporter.C. A defect in the chloride transporter causes a salt imbalance inlung cells.D. Scientists have wondered why the mutant CFTR gene is relativelycommon. In fact, it is the most common mutant gene that causesa severe disease in persons of Northern European descent. Onepossible explanation why…
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From our Case Study on Kimberly: with mucus. is a devastating illness that affects the lungs, pancreas, and intestines-- often causing them to fill In 1989, researchers discovered that the disease is caused by a mutation in a gene that produces a protein that channels chloride across cellular membranes. People with two copies (or alleles) of the mutated gene have a buildup of mucus in the lungs, intestines, and other organs due to nonfunctioning or absent channel proteins. Researchers have found that small-molecule drugs are able to interact directly with disease-causing proteins, blocking their negative effects. O Huntington's disease O Cystic fibrosis O Leber congenital amaurosis O Sickle cell anemia
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