One form of anemia results when individuals have a deficiency in the enzyme phosphatidylinositol glycan A (PIGA). This enzyme is required for the membrane attachment of proteins anchored by glycolipids to the plasma membrane, using what is called a ‘GPI-linkage.’ Included in the group of GPI-linked cell surface proteins is DAF/CD55. These individuals become anemic because:DAF/CD55 prevents the lysis of red blood cells by infecting pathogens.DAF/CD55 normally prevents the spleen from clearing healthy red blood cells from the circulation.In the absence of PIGA, the red blood cell membrane is bare of proteins allowing increased access of complement activating proteins to attach to the cell membrane.DAF/CD55 is a complement inhibitory protein that inactivates any C3 convertase that may form on host cell surfaces.In the absence of PIGA, red blood cells are unable to synthesize high levels of hemoglobin.

Complement decay-accelerating factor (CD55 or DAF) is a protein that is transcribed and translated…

Answered: One form of anemia results when…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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One form of anemia results when individuals have a deficiency in the enzyme phosphatidylinositol glycan A (PIGA). This enzyme is required for the membrane attachment of proteins anchored by glycolipids to the plasma membrane, using what is called a ‘GPI-linkage.’ Included in the group of GPI-linked cell surface proteins is DAF/CD55. These individuals become anemic because:

DAF/CD55 prevents the lysis of red blood cells by infecting pathogens.
DAF/CD55 normally prevents the spleen from clearing healthy red blood cells from the circulation.
In the absence of PIGA, the red blood cell membrane is bare of proteins allowing increased access of complement activating proteins to attach to the cell membrane.
DAF/CD55 is a complement inhibitory protein that inactivates any C3 convertase that may form on host cell surfaces.
In the absence of PIGA, red blood cells are unable to synthesize high levels of hemoglobin.

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