Part of the Ras protein is associated with the plasma membrane, and part extends into the cytoplasm. How does the Ras protein transmit a signal from outside the cell into the cytoplasm? What happens in cases where the ras gene is mutated?
Part of the Ras protein is associated with the plasma membrane,
and part extends into the cytoplasm. How does the Ras protein
transmit a signal from outside the cell into the cytoplasm? What
happens in cases where the ras gene is mutated?
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The answer did not address why most cancer mutations occur upstream of MAPK (ie. RAS (10-20% NRAS mutations), RAF (40-50% BRAF mutation), MEK 1/2 (<10% mutations)) rather than in MAPK (ie. ERK) itself. I give below the question for your re-consideration:
"We saw that most cancer mutations in the RAS/MAPK pathway occur upstream of MAPK rather than in MAPK itself. what might be a reason for that?"
by Bartleby ExpertWe saw that most cancer mutations in the ras/mapk pathway occur upstream of mapk rather than in mapk itself. what might be a reason for that?
by Bartleby Expert
