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- Which of these enzymes is needed to maintain a steady pool of methylene THF used in pyrimidine synthesis and cancer cells proliferation? Group of answer choices Phosphoglyceratedehydrogenase Glyceraldehydegehydrogenase Glycine decarboxylase ThymidylatesynthaseChoose which enzyme is likely deficient based on the symptoms described below: Elevated blood lactate, alanine and pyruvate a) lactate dehydrogenase d) citrate synthase c) pyruvate dehydrogenase d) pyruvate kinaseCHOOSE THE CORRECT LETTER 1.Which of the following molecules are NOT involved in the reaction catalyzed by phosphoglycerate kinase?A.3-phosphoglycerateB.NADHC. 1,3-bisphosphoglycerateD. ATP 2.What is the significance of the Kreb's cycle as a metabolic pathway?A.It allows recovery of energy from carbohydrates only.B.It allows recovery of energy from glucogenic and ketogenic amino acids.C.It allows recovery of energy from fatty acids only.D. It allows recovery of energy from several metabolic fuels that are brokEn down to acetyl-CoA 3.What is the product of glucose metabolism in skeletal muscles in aerobic conditions?A. glycogenB. Acetyl-CoAC. lactateD. acetaldehyde
- CHOOSE THE CORRECT ANSWER. PLS ANSWER. 1.What could be the possible condition that will contribute to the formation and storage of TAGs?A.excessive degradation of muscle proteinsB. too much beta-oxidationC. excess intake of carbohydratesD. increased action of the enzymes of the TCA cycle 2.What of the following molecules can be converted to pyruvate for gluconeogenesis and which is derived from the breakdown of muscle proteins?A.LysineB. AlanineC. LeucineD. IsoleucineFolate deficiency in a cancer patient being treated with 5-Fluorouracil will lead to diminished capacity of this drug to inhibit thymidylate synthase. Group of answer choices True FalseLong explanations are not needed. Direct answers would suffice. a. Transketolases catalyze two-carbon fragment transfer from sedoheptulose-7-phosphate to xylose-5-phosphate. i. True ii. False b. High concentration of NADPH increases the rate of the pentose phosphate pathway by stimulating glucose-6-phosphate dehydrogenase. i. True ii. False
- Consider fructose-1,6-bisphosphatase (FBP) when responding to Parts A, B, and C. When writing your response, please put A, B, or C in front of the answer for each part. NOTE: Each part can be answered in 3-4 sentences.A. State the effect (inhibition OR activation) of insulin signaling on the activity of FBP. Explain why this effect makes sense and make sure you identify the pathway where FBP participates.B. In a type 2 diabetic liver cell, when the blood sugar level is high, will the activity of FBP be HIGHER, LOWER, or THE SAME AS the activity in a nondiabetic liver cell under the same conditions? Explain your reasoning.C. Now think about the insulin and glucagon signaling pathways that control activity of FBP. When a nondiabetic liver cell is exposed to low blood sugar, indicate one specific way the insulin or glucagon signaling pathway could be disrupted so that the activity of FBP is not controlled correctly. Then, explain the reasoning for your answer.Can you explain the oxidation phosphorylation process and its protein complexes? Thank you!Need help, please. For the scenario below relating to Glycogenolysis, please explain how glucose release would be affected. Would it increase, decrease, or result in no change when compared to “normal” conditions? In addition, please identify which enzyme or reaction is affected and why. Scenario: free inorganic phosphate is chelated
- which of the following are possible sources of glyceraldehyde 3-phosphate a. more than 1 correct response b. 2 moles of glucos c. cleavage of fructose-1-6-biphosphate d. dihydroxyacetone phosphatePlease answer the following question: Answer the following questions about Glygogen Metabolism: (But DON’T Just think about glycogen here!) a. After a carbohydrate-filled breakfast, your blood glucose levels increase. How does glucose affect liver glycogen phosphorylase activity? Briefly explain the direct effect (i.e., not via hormones) glucose has on the enzyme, referring to the structure of the enzyme. b. Imagine you develop a drug that targets glycogen synthase kinase as a treatment for Type 2 diabetes. You need to determine if this drug activates or inhibits glycogen synthase kinase? What effect should the drug have on the phosphorylation state and activity of glycogen synthase? Explain in detail your decision. c. Would protein phosphatase 1 (PP1) have to be active or inactive for this drug to be effective? Explain the rationale for your response; be sure to refer to the function of PP1 in your response.CHOOSE THE CORRECT LETTER 1.Which of the following enzymes catalyze the reaction involved in the production of FADHy in the Kreb's cycle?A. malate dehydrogenaseB. a-ketoglutarate dehydrogenaseC.isocitrate dehydrogenaseD. succinate dehydrogenase 2.Steric acid requires eight cycles of B-oxidation to be completely converted to acety/-CoA.A.TrueB. False
