Problem 1: Calculate the hydrolysis of ATP at pH 7 at 37°C under steady state conditions in which the concentration of ATP, ADP and Pi are maintained at 10 ³M, 10 M and 102M, respectively. The AG' of hydrolysis of ATP at pH 7 = -32,217 J/mole, R = 8.314 JK ¹mol-¹, T= 273 +37 K. ATP ADP + Pi
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- Question: Determine the Km and Vmax for this enzyme/substrate combination. [Substrate] (mM) V0 (mM/min) 0.25 0.183 0.50 0.356 1.00 0.665 2.50 1.45 5.00 2.35 What is the concentration of substrate necessary to achieve a turnover rate of 1.00 mM/min?Question: Physical pharmacy 7) Which one of the followings experiments are related to micromeritics? a) Determination of viscosity of liquids. b) Measurement of surface tension c) Determination of flow properties. d) Preparation of calcium carbonate suspension and determination of sedimentation volume. e) Partition coefficient of benzoic acid. Then, explainProblem 2. When alcohol is consumed in excessive quantities, the resulting levels of NADH cause metabolic abnormalities, and one of which is high levels of fatty acid synthesis. Fatty acid synthesis, also a cytoplasmic process, uses acetyl-CoA as a substrate and NADPH as a reducing agent. Based on the above, we can see how acetate is converted to acetyl-CoA in the mitochondria, but fatty acid synthesis takes place in the cytosol. Complete the analysis by accounting for high acetyl-CoA concentration in the cytosol. Study the summary of reactions of citrate metabolism. E. How would increasing the rate of the reaction catalyzed by malate dehydrogenase decrease the concentration of oxaloacetic acid (OAA) in the cytosol? F. How would decreasing the concentration of OAA increase the concentration of acetyl-CoA in the cytosol by Le Chatelier’s principle?
- TASK 1: Prepare a 0.020 M Cupric Sulfate Solution.Capacity of volumetric flask provided: 50 mLCalculation of mass required: *(MM = 249.68 g/mol) Show how you will prepare this. TASK 2: Preparation of a Dilutions of 0.020 M Cupric SulfateDilution 1 - Prepare a 1:2 dilution of 0.020 M Cupric Sulfate for a final volume of 200 mL.How much stock is required to make this solution?Problem 1: For your new year's resolution, you resolve to lose 5lbs of body fat through physical exercise. If you work out hard, you can generate 200 W of mechanical power and be 20% efficient at it. How long will you have to exercise at this rate to burn the desired amount of fat? If you chose to diet instead and cut your food intake of 2400 kcal/day to 1600 kcal/day, how long will it take you to lose the desired amount of weight?Problems 14 and 15: some of the exponents are unclear. Here they are: 14. Calculate vi and the degree of inhibition caused by a competitive inhibitor under the following conditions:(a) [S]=2x10-3 Mand[I]=2x10-3 M(b) [S]=4x10-4 Mand[I]=2x10-3 M (c) [S]=7.5x10-3 Mand[I]=10-5 MAssume that Km = 2 x 10-3 M, Ki = 1.5 x 10-4 M and Vmax = 270 nmoles x liter-1 x min-1.The degree of inhibition is the percent of the uninhibited velocity reached in the presence of the inhibitor. 15. (a) What concentration of competitive inhibitor is required to yield 75% inhibition at a substrate concentration of 1.5 x 10-3 M if Km =2.9x10-4 M and Ki =2x10-5 M? (b)Towhatconcentration must the substrate be increased to reestablish the velocity at theoriginal uninhibited value?
- kinetic values should be more than 10% different(problem 2.25 textbook, see page 41) Stoichiometry and Incomplete Reactions For production of penicillin (C16H18O4N2S) using Penicillium mold, glucose (C6H12O6) is used as a substrate and phenylacetic acid (C8H8O2) is added as a precursor. The stoichiometry for overall synthesis is: 1.67 C6H12O6 + 2NH3 + 0.5O2+ H2SO4 + C8H8O2 à C16H18O4N2S + 2CO2 + 9H2O What is the maximum theoretical yield of penicillin from glucose in g/g? When results from a particular penicillin fermentation were analyzed, it was found that 24% of the glucose had been used for growth, 70% for cell maintenance activities (such as membrane transport and macromolecule turnover) and only 6% for penicillin synthesis. Calculate the yield of penicillin from glucose in g/g under these conditions. Batch fermentation under the conditions described in part b) is carried out in a 100-liter Remember that only 6% of the glucose is used for penicillin synthesis. Initially, the tank is filled with nutrient medium…Yeast Catalase Experiment Questions: 1) What is the purpose of having a 0ml hydrogen peroxide group in a yeast catalase experiment? 2) What reactants contain yeast catalase: H2O2 or yeast mixture? 3) What gas is being given when catalase and hydrogen peroxide react?
- Few question on what did, How did you calculate the pO2 of the patient as 65? Additionally for the percent saturation if the patient's Kd is 48 shouldn't the first half of part a be divided by (48+65)? Why is it divided by 58+pO2? Finally what is meant by oxygen binding cooperativety in the problem?Question:- Q1.Given the following chemical reaction: C6H12O6 + 6 O2 à 6 CO2 + 6 H2O + 36 ATP What process is shown, cellular respiration or photosynthesis? Is this reaction exergonic or endergonic? What are the reactants? Which reactant undergoes oxidation (LEO) to form CO2 What are the products? Which reactant undergoes reduction (GER) to form H2OProblem 3. Excess alcohol consumption can result in fatty liver disease. Liver cells synthesize triacylglycerides from fatty acids formed by fatty acid synthesis. Excess triacylglycerides can accumulate in the liver compromising normal liver function. D.Explain how stimulation of the rate of fatty acid synthesis changes the rate of fatty acid oxidation based on allosteric regulation of the rate-limiting step of beta-oxidation.
